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Frailty trajectorie...
Frailty trajectories in three longitudinal studies of aging : Is the level or the rate of change more predictive of mortality?
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- Bai, Ge (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Szwajda, Agnieszka (author)
- Karolinska Institutet
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- Wang, Yunzhang (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Li, Xia (author)
- Karolinska Institutet
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- Bower, Hannah (author)
- Karolinska Institutet
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- Karlsson, Ida K. (author)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ; School of Health and Welfare, Institute of Gerontology and Aging Research Network—Jönköping (ARN-J), Jönköping University, Sweden
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- Johansson, Boo (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Psykologiska institutionen,Centre for Ageing and Health (Agecap),Department of Psychology
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- Dahl Aslan, Anna K., 1975- (author)
- Karolinska Institutet,Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Välbefinnande vid långvariga hälsoproblem (WeLHP), Wellbeing in Long-term Health Problems,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Skovde, Sch Hlth Sci, Skovde, Sweden.
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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- Hägg, Sara (author)
- Karolinska Institutet
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- Jylhävä, Juulia (author)
- Karolinska Institutet
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (creator_code:org_t)
- 2021-06-11
- 2021
- English.
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In: Age and Ageing. - : Oxford University Press. - 0002-0729 .- 1468-2834. ; 50:6, s. 2174-2182
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Abstract
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- BACKGROUND: frailty shows an upward trajectory with age, and higher levels increase the risk of mortality. However, it is less known whether the shape of frailty trajectories differs by age at death or whether the rate of change in frailty is associated with mortality.OBJECTIVES: to assess population frailty trajectories by age at death and to analyse whether the current level of the frailty index (FI) i.e. the most recent measurement or the person-specific rate of change is more predictive of mortality.METHODS: 3,689 individuals from three population-based cohorts with up to 15 repeated measurements of the Rockwood frailty index were analysed. The FI trajectories were assessed by stratifying the sample into four age-at-death groups: <70, 70-80, 80-90 and >90 years. Generalised survival models were used in the survival analysis.RESULTS: the FI trajectories by age at death showed that those who died at <70 years had a steadily increasing trajectory throughout the 40 years before death, whereas those who died at the oldest ages only accrued deficits from age ~75 onwards. Higher level of FI was independently associated with increased risk of mortality (hazard ratio 1.68, 95% confidence interval 1.47-1.91), whereas the rate of change was no longer significant after accounting for the current FI level. The effect of the FI level did not weaken with time elapsed since the last measurement.CONCLUSIONS: Frailty trajectories differ as a function of age-at-death category. The current level of FI is a stronger marker for risk stratification than the rate of change.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- age at death
- frailty
- mortality
- older people
- trajectories
- Välbefinnande vid långvariga hälsoproblem (WeLHP)
- Wellbeing in long-term health problems (WeLHP)
- age at death
- frailty
- mortality
- older people
- trajectories
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bai, Ge
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Szwajda, Agniesz ...
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Wang, Yunzhang
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Li, Xia
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Bower, Hannah
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Karlsson, Ida K.
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show more...
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Johansson, Boo
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Dahl Aslan, Anna ...
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Pedersen, Nancy ...
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Hägg, Sara
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Jylhävä, Juulia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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Age and Ageing
- By the university
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University of Skövde
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Jönköping University
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Karolinska Institutet
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University of Gothenburg