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Characterization of...
Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden
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- Diaz Cruz, Maria Araceli (författare)
- Jönköping University,HHJ. Biomedicinsk plattform,Research School of Health and Welfare, School of Health and Welfare, University of Jönköping, Jönköping, Sweden,Univ Jonkoping, Sweden
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- Ulfenborg, Benjamin, 1985- (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics,Department of Biology and Bioinformatics, School of Bioscience, University of Skövde, Skövde, Sweden,University of Skövde,Univ Skovde, Sweden
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- Blomstrand, Peter (författare)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Jönköping, Sweden ; Department of Clinical Physiology, County Hospital Ryhov, Jönköping, Sweden ; Unit of Cardiovascular Sciences, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden,Länssjukhuset Ryhov,County Hospital Ryhov,Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Jonkoping Univ, Sweden; Cty Hosp Ryhov, Sweden
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- Faresjö, Maria (författare)
- Department of Biology and Biology Engineering, Chalmers University of Technology, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Sweden
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- Ståhl, Fredrik (författare)
- Högskolan i Borås,Akademin för vård, arbetsliv och välfärd,University of Borås,Boras Univ, Sweden
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- Karlsson, Sandra (författare)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Jönköping, Sweden,Jonkoping Univ, Sweden
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Jönköping University HHJ Biomedicinsk plattform (creator_code:org_t)
- 2022-07-25
- 2022
- Engelska.
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Ingår i: Scientific Reports. - : Nature Portfolio. - 2045-2322. ; 12:1
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Abstract
Ämnesord
Stäng
- Numerous studies have shown that lifestyle factors, such as regular physical activity and vitamin D intake, may remarkably improve overall health and mental wellbeing. This is especially important in older adults whose vitamin D deficiency occurs with a high prevalence. This study aimed to examine the influence of lifestyle and vitamin D on global DNA methylation patterns in an elderly cohort in Southwest of Sweden. We also sought to examine the methylation levels of specific genes involved in vitamin D's molecular and metabolic activated pathways. We performed a genome wide methylation analysis, using Illumina Infinium DNA Methylation EPIC 850kBeadChip array, on 277 healthy individuals from Southwest Sweden at the age of 70-95. The study participants also answered queries on lifestyle, vitamin intake, heart medication, and estimated health. Vitamin D intake did not in general affect methylation patterns, which is in concert with other studies. However, when comparing the group of individuals taking vitamin supplements, including vitamin D, with those not taking supplements, a difference in methylation in the solute carrier family 25 (SCL25A24) gene was found. This confirms a previous finding, where changes in expression of SLC25A24 were associated with vitamin D treatment in human monocytes. The combination of vitamin D intake and high physical activity increased methylation of genes linked to regulation of vitamin D receptor pathway, the Wnt pathway and general cancer processes. To our knowledge, this is the first study detecting epigenetic markers associated with the combined effects of vitamin D supplementation and high physical activity. These results deserve to be further investigated in an extended, interventional study cohort, where also the levels of 25(OH)D3 can be monitored.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Bioinformatik
- Bioinformatics
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