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Subjective experien...
Subjective experiences during dexmedetomidine- or propofol-induced unresponsiveness and non-rapid eye movement sleep in healthy male subjects
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- Valli, Katja, 1973- (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, Turku Brain and Mind Center, University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience
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- Radek, Linda (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland
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- Kallionpää, Roosa E. (författare)
- Department of Psychology and Speech-Language Pathology, Turku Brain and Mind Center, University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland
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- Scheinin, Annalotta (författare)
- Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Turku PET Centre, University of Turku and Turku University Hospital, Finland
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- Långsjö, Jaakko (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland ; Department of Intensive Care, Tampere University Hospital, Tampere, Finland
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- Kaisti, Kaike (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland ; Department of Anesthesiology and Intensive Care, Oulu University Hospital, Finland
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- Kantonen, Oskari (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland
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- Korhonen, Jarno (författare)
- Department of Psychology and Speech-Language Pathology, Turku Brain and Mind Center, University of Turku, Finland
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- Vahlberg, Tero (författare)
- Institute of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Finland
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- Revonsuo, Antti (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, Turku Brain and Mind Center, University of Turku, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience
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- Scheinin, Harry (författare)
- Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Turku PET Centre, University of Turku and Turku University Hospital, Finland ; Institute of Biomedicine and Unit of Clinical Pharmacology, University of Turku and Turku University Hospital, Finland
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: British Journal of Anaesthesia. - : Elsevier. - 0007-0912 .- 1471-6771. ; 131:2, s. 348-359
- Relaterad länk:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Anaesthetic-induced unresponsiveness and non-rapid eye movement (NREM) sleep share common neural pathways and neurophysiological features. We hypothesised that these states bear resemblance also at the experiential level. Methods: We compared, in a within-subject design, the prevalence and content of experiences in reports obtained after anaesthetic-induced unresponsiveness and NREM sleep. Healthy males (N=39) received dexmedetomidine (n=20) or propofol (n=19) in stepwise doses to induce unresponsiveness. Those rousable were interviewed and left unstimulated, and the procedure was repeated. Finally, the anaesthetic dose was increased 50%, and the participants were interviewed after recovery. The same participants (N=37) were also later interviewed after NREM sleep awakenings. Results: Most subjects were rousable, with no difference between anaesthetic agents (P=0.480). Lower drug plasma concentrations were associated with being rousable for both dexmedetomidine (P=0.007) and propofol (P=0.002) but not with recall of experiences in either drug group (dexmedetomidine: P=0.543; propofol: P=0.460). Of the 76 and 73 interviews performed after anaesthetic-induced unresponsiveness and NREM sleep, 69.7% and 64.4% included experiences, respectively. Recall did not differ between anaesthetic-induced unresponsiveness and NREM sleep (P=0.581), or between dexmedetomidine and propofol in any of the three awakening rounds (P>0.05). Disconnected dream-like experiences (62.3% vs 51.1%; P=0.418) and memory incorporation of the research setting (88.7% vs 78.7%; P=0.204) were equally often present in anaesthesia and sleep interviews, respectively, whereas awareness, signifying connected consciousness, was rarely reported in either state. Conclusions: Anaesthetic-induced unresponsiveness and NREM sleep are characterised by disconnected conscious experiences with corresponding recall frequencies and content. Clinical trial registration: Clinical trial registration. This study was part of a larger study registered at ClinicalTrials.gov (NCT01889004).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Tillämpad psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Applied Psychology (hsv//eng)
Nyckelord
- anaesthesia
- awareness
- consciousness
- dexmedetomidine
- dreaming
- propofol
- sleep
- unresponsiveness
- Consciousness and Cognitive Neuroscience
- Kognitiv neurovetenskap och filosofi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Valli, Katja, 19 ...
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Radek, Linda
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Kallionpää, Roos ...
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Scheinin, Annalo ...
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Långsjö, Jaakko
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Kaisti, Kaike
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visa fler...
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Kantonen, Oskari
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Korhonen, Jarno
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Vahlberg, Tero
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Revonsuo, Antti
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Scheinin, Harry
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