SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:his-23313"
 

Search: onr:"swepub:oai:DiVA.org:his-23313" > Regional transcript...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Sandstedt, Mikael,1990Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine (author)

Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria as well as all chambers of the failing human heart

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Physiological Society,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:his-23313
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23313URI
  • https://doi.org/10.1152/ajpheart.00438.2023DOI
  • https://gup.ub.gu.se/publication/332156URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • This study was funded by grants from the Swedish Society of Medicine, the Gothenburg Society of Medicine, the Heart-Lung Foundation, the Emelle Foundation, the foundations of the Sahlgrenska University Hospital, the University of Skövde, the Swedish Knowledge Foundation, the foundation Research Without Animal Experiments, and the Swedish Royal Academy and by ALF research grants from the Sahlgrenska University Hospital.
  • The different chambers of the human heart demonstrate regional physiological traits and may be differentially affected during pathologic remodeling, resulting in heart failure. Few previous studies have, however, characterized the different chambers at a transcriptomic level. We therefore conducted whole-tissue RNA sequencing and gene set enrichment analysis of biopsies collected from the four chambers of adult failing (n = 8) and nonfailing (n = 11) human hearts. Atria and ventricles demonstrated distinct transcriptional patterns. Compared to nonfailing ventricles, the transcriptional pattern of nonfailing atria was enriched for a large number of gene sets associated with cardiogenesis, the immune system and bone morphogenetic protein (BMP), transforming growth factor beta (TGF beta), MAPK/JNK and Wnt signaling. Differences between failing and nonfailing hearts were also determined. The transcriptional pattern of failing atria was distinct compared to that of nonfailing atria and enriched for gene sets associated with the innate and adaptive immune system, TGF beta/SMAD signaling, and changes in endothelial, smooth muscle cell and cardiomyocyte physiology. Failing ventricles were also enriched for gene sets associated with the immune system. Based on the transcriptomic patterns, upstream regulators associated with heart failure were identified. These included many immune response factors predicted to be similarly activated for all chambers of failing hearts. In summary, the heart chambers demonstrate distinct transcriptional patterns that differ between failing and nonfailing hearts. Immune system signaling may be a hallmark of all four heart chambers in failing hearts, and could constitute a novel therapeutic target.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vukusic, Kristina,1979Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xkajkr (author)
  • Johansson, MarkusHögskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics(Swepub:his)oham (author)
  • Jonsson, Marianne,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xjmare (author)
  • Magnusson, Rasmus,1992-Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics(Swepub:his)magr (author)
  • Mattsson Hultén, Lillemor,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xmatli (author)
  • Dellgren, Göran,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xdelgo (author)
  • Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjepan (author)
  • Lindahl, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xlandy (author)
  • Synnergren, JaneGothenburg University,Göteborgs universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsynja (author)
  • Sandstedt, JoakimGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xsjoad (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för laboratoriemedicin (creator_code:org_t)

Related titles

  • In:American Journal of Physiology. Heart and Circulatory Physiology: American Physiological Society325:6, s. H1430-H14450363-61351522-1539

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view