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Metabolomics for ea...
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Borgmästars, EmmyUmeå universitet,Kirurgi
(författare)
Metabolomics for early pancreatic cancer detection in plasma samples from a Swedish prospective population-based biobank
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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AME Publishing Company,2024
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-23791
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23791URI
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https://doi.org/10.21037/jgo-23-930DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224962URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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CC BY-NC-ND 4.0 DEEDCorrespondence to: Emmy Borgmästars, PhD. Department of Surgical and Perioperative Sciences/Surgery, Umeå University, Norrlands Universitetssjukhus, 6M, M31, 901 85 Umeå, Sweden. Email: emmy.borgmastars@umu.seThis work was supported by Umeå University, the Swedish Cancer Society (19 0273, 2017-557, CAN 2017/332, CAN 2017/827), the Swedish Research Council (2019-01690, 2016-02990, 2017-01531), Västerbotten Region (RV-583411, RV-549731, RV-841551, RV-930167, VLL-643451, RV-930478, RV-930132, RV-9960708, RV-99607108, VLL-837731), the Sjöberg Foundation, the Claes Groschinsky Memorial Foundation (M 19391), Bengt Ihre Foundation (SLS-885861, SLS-960529), Swedish Society of Medicine (SLS-960379), Lion’s Cancer Research Foundation, the Knut and Alice Wallenberg Foundation, Finska Läkaresällskapet, the Sigrid Juselius Foundation, Medicinska Understödsföreningen Liv och Hälsa, Bengt Ihre Fellowship Research Grant, and the JC Kempe Memorial Foundation Scholarship Fund.
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Background: Pancreatic ductal adenocarcinoma (pancreatic cancer) is often detected at late stages resulting in poor overall survival. To improve survival, more patients need to be diagnosed early when curative surgery is feasible. We aimed to identify circulating metabolites that could be used as early pancreatic cancer biomarkers.Methods: We performed metabolomics by liquid and gas chromatography-mass spectrometry in plasma samples from 82 future pancreatic cancer patients and 82 matched healthy controls within the Northern Sweden Health and Disease Study (NSHDS). Logistic regression was used to assess univariate associations between metabolites and pancreatic cancer risk. Least absolute shrinkage and selection operator (LASSO) logistic regression was used to design a metabolite-based risk score. We used receiver operating characteristic (ROC) analyses to assess the discriminative performance of the metabolite-based risk score.Results: Among twelve risk-associated metabolites with a nominal P value <0.05, we defined a risk score of three metabolites [indoleacetate, 3-hydroxydecanoate (10:0-OH), and retention index (RI): 2,745.4] using LASSO. A logistic regression model containing these three metabolites, age, sex, body mass index (BMI), smoking status, sample date, fasting status, and carbohydrate antigen 19-9 (CA 19-9) yielded an internal area under curve (AUC) of 0.784 [95% confidence interval (CI): 0.714–0.854] compared to 0.681 (95% CI: 0.597–0.764) for a model without these metabolites (P value =0.007). Seventeen metabolites were significantly associated with pancreatic cancer survival [false discovery rate (FDR) <0.1].Conclusions: Indoleacetate, 3-hydroxydecanoate (10:0-OH), and RI: 2,745.4 were identified as the top candidate biomarkers for early detection. However, continued efforts are warranted to determine the usefulness of these metabolites as early pancreatic cancer biomarkers.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jacobson, SaraUmeå universitet,Kirurgi(Swepub:umu)saja0030
(författare)
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Simm, MajaUmeå universitet,Obstetrik och gynekologi,Kirurgi(Swepub:umu)makr0062
(författare)
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Johansson, MattiasGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Billing, Ola,1981-Umeå universitet,Kirurgi(Swepub:umu)olabig00
(författare)
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Lundin, Christina,1970-Umeå universitet,Kirurgi(Swepub:umu)chlu0008
(författare)
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Nyström, Hanna,1980-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Kirurgi(Swepub:umu)haanym01
(författare)
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Öhlund, Daniel,1979-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)dalohd00
(författare)
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Lubovac-Pilav, ZelminaHögskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics,Department of Biology and Bioinformatics, University of Skövde, Skövde, Sweden(Swepub:his)lubz
(författare)
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Jonsson, PärUmeå universitet,Kemiska institutionen(Swepub:umu)parjon95
(författare)
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Franklin, Oskar,1985-Umeå universitet,Kirurgi,Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, CO, Aurora, United States(Swepub:umu)osfr0002
(författare)
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Sund, MalinUmeå universitet,Kirurgi,Department of Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021
(författare)
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Umeå universitetKirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Gastrointestinal Oncology: AME Publishing Company15:2, s. 755-7672078-68912219-679X
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