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  • Meng, NDepartment of Surgery, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China (author)

RECK, a novel matrix metalloproteinase regulator

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Hernandéz,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:his-2752
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-2752URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43640URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Extracellular matrix (ECM) macromolecules are important for creating the cellular environments required during development and morphogenesis of tissues. Matrix metalloproteinases (MMPs) are a family of Zn-dependent endopeptidases that collectively are capable of cleaving virtually all ECM substrates, and play an important role in some physiological and pathological processes. MMP activity can be inhibited by some natural and artificial inhibitors. A newly found membrane-anchored regulator of MMPs, the reversion-inducing-cysteine-rich protein with kazal motifs (RECK), is downregulated when the cells undergo a process of malignant transformation, and is currently the subject of considerable research activity because of its specific structure and function. In this review, we have chosen to concentrate our efforts on the structure, function, regulation, and future prospect of RECK in order to provide a new target for prevention and treatment of tumours

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  • Li, YDepartment of Surgery, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China (author)
  • Zhang, HongHögskolan i Skövde,Institutionen för vård och natur,Division of Biomedicine School of Life Science, University of Skövde, Skövde,(Swepub:his)zhah (author)
  • Sun, Xiao-Feng,1959-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
  • Department of Surgery, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaInstitutionen för vård och natur (creator_code:org_t)

Related titles

  • In:Histology and Histopathology: Hernandéz23:8, s. 1003-10100213-39111699-5848

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Meng, N
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Zhang, Hong
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NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Biochemistry and ...
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Histology and Hi ...
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University of Skövde
Linköping University

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