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Knockdown of peroxi...
Knockdown of peroxisome proliferator-activated receptor-β induces less differentiation and enhances cell-fibronectinadhesion of colon cancer cells
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- Yang, L. (author)
- Linköping University
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- Olsson, B. (author)
- Linköping University
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- Pfeifer, D. (author)
- Linköping University
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- Jönsson, J.-I. (author)
- Linköping University
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- Zhou, Z.-G. (author)
- Sichuan University
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- Jiang, X. (author)
- Sichuan University
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- Fredriksson, B.-A. (author)
- Linköping University
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- Zhang, Hong (author)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi
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- Sun, X.-F. (author)
- Linköping University
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(creator_code:org_t)
- 2009-11-23
- 2010
- English.
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In: Oncogene. - : Nature publishing group. - 0950-9232 .- 1476-5594. ; 29:4, s. 516-526
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The role of peroxisome proliferator-activated receptor-/ (PPAR-/) in the pathogenesis of colon cancer remains highly controversial. This study specifically silenced the PPAR- expression in three colon cancer cell lines with different metastatic potentials. Although PPAR-knockdown resulted in more malignant morphological changes, bigger colony sizes and lower carcinoembryonic antigen (CEA) secretion, and enhanced the cell-fibronectin adhesion, cell invasion and migration were unaffected. These effects were stronger in poorly metastatic cell lines compared with highly metastatic ones. Simultaneously, PPAR-knockdown decreased the mRNAs encoding adipocyte differentiation-related protein and liver fatty acid binding protein, and increased the mRNA of ILK, whereas the mRNAs encoding integrin-1 and angiopoietin-like 4 were unchanged. Using immunohistochemistry, we determined that the intensity of PPAR- expression was stronger in rectal cancers with better differentiation than in those with poor differentiation, and was stronger in early-stage tumors than in advanced ones. Together, these findings consistently indicate that PPAR- may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer, having a role as an inhibitor in the carcinogenesis and progression of colorectal cancer. Interestingly PPAR- seems to have a more important role in poorly metastatic cells than in highly metastatic ones.
Keyword
- Naturvetenskap
- Natural sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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