Sökning: WFRF:(Fredriksson L. A.)
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Knockdown of peroxi...
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Yang, L.Linköping University
(författare)
Knockdown of peroxisome proliferator-activated receptor-β induces less differentiation and enhances cell-fibronectinadhesion of colon cancer cells
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2009-11-23
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Nature publishing group,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-3661
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3661URI
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https://doi.org/10.1038/onc.2009.370DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The role of peroxisome proliferator-activated receptor-/ (PPAR-/) in the pathogenesis of colon cancer remains highly controversial. This study specifically silenced the PPAR- expression in three colon cancer cell lines with different metastatic potentials. Although PPAR-knockdown resulted in more malignant morphological changes, bigger colony sizes and lower carcinoembryonic antigen (CEA) secretion, and enhanced the cell-fibronectin adhesion, cell invasion and migration were unaffected. These effects were stronger in poorly metastatic cell lines compared with highly metastatic ones. Simultaneously, PPAR-knockdown decreased the mRNAs encoding adipocyte differentiation-related protein and liver fatty acid binding protein, and increased the mRNA of ILK, whereas the mRNAs encoding integrin-1 and angiopoietin-like 4 were unchanged. Using immunohistochemistry, we determined that the intensity of PPAR- expression was stronger in rectal cancers with better differentiation than in those with poor differentiation, and was stronger in early-stage tumors than in advanced ones. Together, these findings consistently indicate that PPAR- may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer, having a role as an inhibitor in the carcinogenesis and progression of colorectal cancer. Interestingly PPAR- seems to have a more important role in poorly metastatic cells than in highly metastatic ones.
Ämnesord och genrebeteckningar
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Naturvetenskap
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Natural sciences
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Olsson, B.Linköping University
(författare)
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Pfeifer, D.Linköping University
(författare)
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Jönsson, J.-I.Linköping University
(författare)
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Zhou, Z.-G.Sichuan University
(författare)
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Jiang, X.Sichuan University
(författare)
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Fredriksson, B.-A.Linköping University
(författare)
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Zhang, HongHögskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi(Swepub:his)zhah
(författare)
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Sun, X.-F.Linköping University
(författare)
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Linköping UniversitySichuan University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Oncogene: Nature publishing group29:4, s. 516-5260950-92321476-5594
Internetlänk
Hitta via bibliotek
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Oncogene
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