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Returning from Obli...
Returning from Oblivion : Imaging the Neural Core of Consciousness
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- Långsjö, Jaakko W. (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Anesthesiology, Seinäjoki Central Hospital, Finland
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- Alkire, Michael T. (författare)
- VA Long Beach Healthcare system (Long Beach, California, 90822), Department of Anesthesiology & Perioperative Care and the Center for the Neurobiology of Learning and Memory, University of California-Irvine, USA
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- Kaskinoro, Kimmo (författare)
- Department of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine, Turku University Hospital, Finland
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- Hayama, Hiroki (författare)
- VA Long Beach Healthcare system (Long Beach, California, 90822), Department of Anesthesiology & Perioperative Care and the Center for the Neurobiology of Learning and Memory, University of California-Irvine, USA
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- Maksimow, Anu (författare)
- Department of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine, Turku University Hospital, Finland
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- Kaisti, Kaike K. (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland
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- Aalto, Sargo (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland
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- Aantaa, Riku (författare)
- Department of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine, Turku University Hospital, Finland
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- Jääskeläinen, Satu K. (författare)
- Department of Clinical Neurophysiology, Turku University Hospital, Finland
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- Revonsuo, Antti (författare)
- Högskolan i Skövde,Institutionen för kommunikation och information,Forskningscentrum för Systembiologi,Kognitiv neurovetenskap och filosofi, Consciousness and Cognitive Neuroscience
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- Scheinin, Harry (författare)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Finland / Pulssi Medical Centre, Turku, Finland
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(creator_code:org_t)
- Society for Neuroscience, 2012
- 2012
- Engelska.
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Ingår i: Journal of Neuroscience. - : Society for Neuroscience. - 0270-6474 .- 1529-2401. ; 32:14, s. 4935-4943
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https://his.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- One of the greatest challenges of modern neuroscience is to discover the neural mechanisms of consciousness and to explain how they produce the conscious state. We sought the underlying neural substrate of human consciousness by manipulating the level of consciousness in volunteers with anesthetic agents and visualizing the resultant changes in brain activity using regional cerebral blood flow imaging with positron emission tomography. Study design and methodology were chosen to dissociate the state-related changes in consciousness from the effects of the anesthetic drugs. We found the emergence of consciousness, as assessed with a motor response to a spoken command, to be associated with the activation of a core network involving subcortical and limbic regions that become functionally coupled with parts of frontal and inferior parietal cortices upon awakening from unconsciousness. The neural core of consciousness thus involves forebrain arousal acting to link motor intentions originating in posterior sensory integration regions with motor action control arising in more anterior brain regions. These findings reveal the clearest picture yet of the minimal neural correlates required for a conscious state to emerge.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Natural sciences
- Naturvetenskap
- Consciousness and Cognitive Neuroscience
- Kognitiv neurovetenskap och filosofi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Långsjö, Jaakko ...
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Alkire, Michael ...
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Kaskinoro, Kimmo
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Hayama, Hiroki
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Maksimow, Anu
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Kaisti, Kaike K.
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visa fler...
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Aalto, Sargo
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Aantaa, Riku
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Jääskeläinen, Sa ...
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Revonsuo, Antti
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Scheinin, Harry
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visa färre...
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Högskolan i Skövde