Sökning: WFRF:(Bharadwaj Mausumi) >
Association of cycl...
Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley : a high risk area
-
- Hussain, Showket (författare)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
-
- M., Yuvaraj (författare)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
-
- Thakur, Nisha (författare)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
-
visa fler...
-
- Salam, Irfana (författare)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
-
- Singh, Neha (författare)
- Panjab University, Chandigarh, India
-
- Mir, Mohammad Muzaffar (författare)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
-
- Bhat, Mohammad Akbar (författare)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
-
- Siddiqi, Mushtaq A. (författare)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
-
- Das, Bhudev C. (författare)
- Dr. B.R. Ambedkar Research Centre for Biomedical Research (ACBR), University of Delhi, India
-
- Bharadwaj, Mausumi (författare)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
-
visa färre...
-
(creator_code:org_t)
- 2011-01-25
- 2011
- Engelska.
-
Ingår i: Molecular Carcinogenesis. - : Wiley-Blackwell. - 0899-1987 .- 1098-2744. ; 50:7, s. 487-98
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Investigation of potential association of SNPs (G870A, rs9344; G1722C, rs678653) of cyclin D1 gene (CCND1) with susceptibility to esophageal squamous cell carcinoma (ESCC) in Kashmir valley (India). The study included 302 subjects comprising 151 ESCC cases and 151 controls. PCR-RFLP and direct sequencing were employed for genotyping. The G870A polymorphism, the individuals carrying GA + AA genotype was having 2.80-fold increased risk for development of ESCC (OR 2.8, 95% CI = 1.77-4.4; P = 0.0001) compared to GG genotype. Further a significantly higher risk was observed in individuals who consume >3 cups per day of salted tea (OR = 5.1; 95% CI = 1.6-16.7; P = 0.0016) and had smoking habits (OR = 6.3; 95% CI = 2.9-13.9; P = 0.0005). We also demonstrate for the first time in CCND1 1722 locus, the CC genotype was strongly associated with increased risk of developing ESCC (OR = 2.58; 95% CI = 1.61-4.15; P = 0.0001). In addition, the frequency of polymorphic C allele was also found to be higher in cases (OR = 1.92; 95% CI = 1.37-2.69; P = 0.0002). There appears to be an influence of CCND1 G870A/G1772C genotypes on genetic susceptibility to ESCC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- CCND1
- esophageal cancer
- Kashmir; gene polymorphism
- Naturvetenskap
- Natural sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hussain, Showket
-
M., Yuvaraj
-
Thakur, Nisha
-
Salam, Irfana
-
Singh, Neha
-
Mir, Mohammad Mu ...
-
visa fler...
-
Bhat, Mohammad A ...
-
Siddiqi, Mushtaq ...
-
Das, Bhudev C.
-
Bharadwaj, Mausu ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Molecular Carcin ...
- Av lärosätet
-
Högskolan i Skövde