Disease course, outcome, and predictors of outcome in a population-based juvenile chronic arthritis cohort followed for 17 years

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Bertilsson, LennartGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (författare)

Disease course, outcome, and predictors of outcome in a population-based juvenile chronic arthritis cohort followed for 17 years

Artikel/kapitelEngelska2013

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2013-02-15
The Journal of Rheumatology,2013
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:hj-22880
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-22880URI
https://doi.org/10.3899/jrheum.120602DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105290URI
https://gup.ub.gu.se/publication/173905URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

OBJECTIVE: To investigate disease course, outcome, and predictors of outcome in an unselected population-based cohort of individuals diagnosed with juvenile chronic arthritis (JCA) followed for 17 years. METHODS: The cohort consisted of 132 incidence JCA cases identified 1984-1986 according to EULAR criteria. At 5-year followup, 129 individuals underwent joint assessment, laboratory measurements, radiographic examination, and medication and functional assessment. At 17-year followup, 86 were examined with joint assessment, laboratory measurements, medication assessment, Health Assessment Questionnaire (HAQ), Keitel functional test (KFT), and Medical Outcomes Study Short Form-36 (SF-36). RESULTS: At 17-year followup, 40% were in remission, 44% changed subgroups, median HAQ score was 0.0 (range 0.0-1.5), and median KFT was 100 (range 54-100). SF-36 scores were significantly lower compared to a reference group. Thirty-nine percent of those in remission at 5-year followup were not in remission at 17-year followup. In multivariate analyses of variables from the 17-year followup: remission was predicted by remission at 5-year followup (OR 4.8); HAQ > 0 by rheumatoid factor (RF)-positivity at 5-year followup (OR 3.6); KFT < 100 by nonremission (OR 11.3); and RF-positivity (OR 5.6) at 5-year followup; and the SF-36 physical component summary score above average of the reference group by remission at 5-year followup (OR 5.8). CONCLUSION: This longterm study of 86 individuals with JCA showed large variability of disease courses and of impaired health-related quality of life. Sixty percent were not in remission at 17-year followup. Longterm outcome was best predicted by and associated with characteristics at 5-year followup rather than those at onset.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
Adolescent
Age of Onset
Antirheumatic Agents/therapeutic use
Arthritis
Juvenile/drug therapy/epidemiology/ pathology/ physiopathology
Cohort Studies
Female
Health Status
Humans
Male
Prognosis
Quality of Life
Recovery of Function
Remission Induction
Sweden/epidemiology
Symptom Assessment
Treatment Outcome
Young Adult
juvenile chronic arthritis
juvenile idiopathic arthritis
juvenile rheumatoid arthritis
outcome assessment
prognosis

Biuppslag (personer, institutioner, konferenser, titlar ...)

Andersson-Gäre, BoelJönköping University,The Jönköping Academy for Improvement of Health and Welfare,HHJ. Kvalitetsförbättring och ledarskap inom hälsa och välfärd(Swepub:hj)andboe (författare)
Fasth, Anders,1945Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Department of Pediatrics, University of Gothenburg(Swepub:gu)xfasan (författare)
Petersson, Ingemar F.Department of Orthopedics, Clinical Sciences, and Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund (författare)
Forsblad-D'elia, HelenaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Department of Rheumatology and Inflammation Research, University of Gothenburg(Swepub:gu)xforhe (författare)
Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Rheumatology: The Journal of Rheumatology40:5, s. 715-7240315-162X1499-2752

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Av författaren/redakt...: Bertilsson, Lenn ...; Andersson-Gäre, ...; Fasth, Anders, 1 ...; Petersson, Ingem ...; Forsblad-D'elia, ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

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Av lärosätet: Jönköping University; Umeå universitet; Göteborgs universitet

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