Search: id:"swepub:oai:DiVA.org:hj-25614" >
Subjective cognitiv...
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Garcia-Ptacek, SaraKarolinska Institutet
(author)
Subjective cognitive impairment subjects in our clinical practice
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-11-11
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S. Karger AG,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:hj-25614
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-25614URI
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https://doi.org/10.1159/000366270DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:225538726URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND:The clinical challenge in subjective cognitive impairment (SCI) is to identify which individuals will present cognitive decline. We created a statistical model to determine which variables contribute to SCI and mild cognitive impairment (MCI) versus Alzheimer's disease (AD) diagnoses.METHODS:A total of 993 subjects diagnosed at a memory clinic (2007-2009) were included retrospectively: 433 with SCI, 373 with MCI and 187 with AD. Descriptive statistics were provided. A logistic regression model analyzed the likelihood of SCI and MCI patients being diagnosed with AD, using age, gender, Mini-Mental State Examination score, the ratio of β-amyloid 42 divided by total tau, and phosphorylated tau as independent variables.RESULTS:The SCI subjects were younger (57.8 ± 8 years) than the MCI (64.2 ± 10.6 years) and AD subjects (70.1 ± 9.7 years). They were more educated, had less medial temporal lobe atrophy (MTA) and frequently normal cerebrospinal fluid biomarkers. Apolipoprotein E4/E4 homozygotes and apolipoprotein E3/E4 heterozygotes were significantly less frequent in the SCI group (6 and 36%) than in the AD group (28 and 51%). Within the regression model, cardiovascular risk factors, confluent white matter lesions, MTA and central atrophy increased the AD likelihood for SCI subjects.CONCLUSIONS:SCI patients form a distinct group. In our model, factors suggesting cardiovascular risk, MTA and central atrophy increased the AD likelihood for SCI subjects.
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Cavallin, LenaKarolinska Institutet
(author)
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Kåreholt, IngemarKarolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi(Swepub:hj)karing
(author)
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Kramberger, Milica GregoricKarolinska Institutet Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Sweden
(author)
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Winblad, BengtKarolinska Institutet
(author)
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Jelic, VesnaKarolinska Institutet
(author)
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Eriksdotter, MariaKarolinska Institutet
(author)
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Karolinska InstitutetHHJ, Institutet för gerontologi
(creator_code:org_t)
Related titles
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In:Dementia and Geriatric Cognitive Disorders Extra: S. Karger AG4:3, s. 419-4301664-5464
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