Subjective cognitive impairment subjects in our clinical practice

BACKGROUND:The clinical challenge in subjective cognitive impairment (SCI) is to identify which individuals will present cognitive decline. We created a statistical model to determine which variables contribute to SCI and mild cognitive impairment (MCI) versus Alzheimer's disease (AD) diagnoses.METHODS:A total of 993 subjects diagnosed at a memory clinic (2007-2009) were included retrospectively: 433 with SCI, 373 with MCI and 187 with AD. Descriptive statistics were provided. A logistic regression model analyzed the likelihood of SCI and MCI patients being diagnosed with AD, using age, gender, Mini-Mental State Examination score, the ratio of β-amyloid 42 divided by total tau, and phosphorylated tau as independent variables.RESULTS:The SCI subjects were younger (57.8 ± 8 years) than the MCI (64.2 ± 10.6 years) and AD subjects (70.1 ± 9.7 years). They were more educated, had less medial temporal lobe atrophy (MTA) and frequently normal cerebrospinal fluid biomarkers. Apolipoprotein E4/E4 homozygotes and apolipoprotein E3/E4 heterozygotes were significantly less frequent in the SCI group (6 and 36%) than in the AD group (28 and 51%). Within the regression model, cardiovascular risk factors, confluent white matter lesions, MTA and central atrophy increased the AD likelihood for SCI subjects.CONCLUSIONS:SCI patients form a distinct group. In our model, factors suggesting cardiovascular risk, MTA and central atrophy increased the AD likelihood for SCI subjects.

Cavallin, LenaKarolinska Institutet (author)
Kåreholt, IngemarKarolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi(Swepub:hj)karing (author)
Kramberger, Milica GregoricKarolinska Institutet Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Sweden (author)
Winblad, BengtKarolinska Institutet (author)
Jelic, VesnaKarolinska Institutet (author)
Eriksdotter, MariaKarolinska Institutet (author)
Karolinska InstitutetHHJ, Institutet för gerontologi (creator_code:org_t)

In:Dementia and Geriatric Cognitive Disorders Extra: S. Karger AG4:3, s. 419-4301664-5464

By the author/editor: Garcia-Ptacek, S ...; Cavallin, Lena; Kåreholt, Ingema ...; Kramberger, Mili ...; Winblad, Bengt; Jelic, Vesna; show more...; Eriksdotter, Mar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Other Medical an ...; and Gerontology spec ...

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