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Study of 300,486 in...
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
- Article/chapterEnglish2018
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2018-05-29
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Nature Publishing Group,2018
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:hj-41589
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-41589URI
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https://doi.org/10.1038/s41467-018-04362-xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149020URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-157720URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138360071URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
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General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
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Lam, M.
(author)
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Harris, S. E.
(author)
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Trampush, J. W.
(author)
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Luciano, M.
(author)
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Hill, W. D.
(author)
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Hagenaars, S. P.
(author)
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Ritchie, S. J.
(author)
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Marioni, R. E.
(author)
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Fawns-Ritchie, C.
(author)
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Liewald, D. C. M.
(author)
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Okely, J. A.
(author)
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Ahola-Olli, A. V.
(author)
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Barnes, C. L. K.
(author)
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Bertram, L.
(author)
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Bis, J. C.
(author)
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Burdick, K. E.
(author)
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Christoforou, A.
(author)
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Derosse, P.
(author)
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Djurovic, S.
(author)
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Espeseth, T.
(author)
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Giakoumaki, S.
(author)
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Giddaluru, S.
(author)
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Gustavson, D. E.
(author)
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Hayward, C.
(author)
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Hofer, E.
(author)
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Ikram, M. A.
(author)
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Karlsson, R.Karolinska Institutet
(author)
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Knowles, E.
(author)
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Lahti, J.
(author)
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Leber, M.
(author)
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Li, S.
(author)
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Mather, K. A.
(author)
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Melle, I.
(author)
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Morris, D.
(author)
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Oldmeadow, C.
(author)
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Palviainen, T.
(author)
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Payton, A.
(author)
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Pazoki, R.
(author)
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Petrovic, K.
(author)
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Reynolds, C. A.
(author)
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Sargurupremraj, M.
(author)
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Scholz, M.
(author)
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Smith, J. A.
(author)
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Smith, A. V.
(author)
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Terzikhan, N.
(author)
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Thalamuthu, A.
(author)
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Trompet, S.
(author)
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Van Der Lee, S. J.
(author)
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Ware, E. B.
(author)
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Windham, B. G.
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Wright, M. J.
(author)
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Yang, J.
(author)
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Yu, J.
(author)
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Ames, D.
(author)
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Amin, N.
(author)
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Amouyel, P.
(author)
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Andreassen, O. A.
(author)
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Armstrong, N. J.
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Assareh, A. A.
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Attia, J. R.
(author)
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Attix, D.
(author)
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Avramopoulos, D.
(author)
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Bennett, D. A.
(author)
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Böhmer, A. C.
(author)
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Boyle, P. A.
(author)
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Brodaty, H.
(author)
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Campbell, H.
(author)
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Cannon, T. D.
(author)
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Cirulli, E. T.
(author)
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Congdon, E.
(author)
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Conley, E. D.
(author)
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Corley, J.
(author)
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Cox, S. R.
(author)
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Dale, A. M.
(author)
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Dehghan, A.
(author)
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Dick, D.
(author)
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Dickinson, D.
(author)
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Eriksson, J. G.
(author)
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Evangelou, E.
(author)
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Faul, J. D.
(author)
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Ford, I.
(author)
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Freimer, N. A.
(author)
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Gao, H.
(author)
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Giegling, I.
(author)
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Gillespie, N. A.
(author)
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Gordon, S. D.
(author)
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Gottesman, R. F.
(author)
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Griswold, M. E.
(author)
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Gudnason, V.
(author)
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Harris, T. B.
(author)
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Hartmann, A. M.
(author)
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Hatzimanolis, A.
(author)
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Heiss, G.
(author)
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Holliday, E. G.
(author)
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Joshi, P. K.
(author)
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Kähönen, M.
(author)
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Kardia, S. L. R.
(author)
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Karlsson, Ida K.Karolinska Institutet(Swepub:hj)karida
(author)
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Kleineidam, L.
(author)
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Knopman, D. S.
(author)
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Kochan, N. A.
(author)
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Konte, B.
(author)
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Kwok, J. B.
(author)
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Le Hellard, S.
(author)
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Lee, T.
(author)
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Lehtimäki, T.
(author)
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Li, S. -C
(author)
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Liu, T.
(author)
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Koini, M.
(author)
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London, E.
(author)
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Longstreth, W.T., Jr.
(author)
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Lopez, O. L.
(author)
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Loukola, A.
(author)
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Luck, T.
(author)
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Lundervold, A. J.
(author)
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Lundquist, Anders,1978-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Statistik(Swepub:umu)anslst97
(author)
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Lyytikäinen, L. -PKarolinska Institutet
(author)
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Martin, N. G.
(author)
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Montgomery, G. W.
(author)
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Murray, A. D.
(author)
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Need, A. C.
(author)
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Noordam, R.
(author)
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Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001
(author)
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Ollier, W.
(author)
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Papenberg, G.Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Germany
(author)
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Pattie, A.
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Polasek, O.
(author)
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Poldrack, R. A.
(author)
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Psaty, B. M.
(author)
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Reppermund, S.
(author)
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Riedel-Heller, S. G.
(author)
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Rose, R. J.
(author)
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Rotter, J. I.
(author)
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Roussos, P.
(author)
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Rovio, S. P.
(author)
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Saba, Y.
(author)
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Sabb, F. W.
(author)
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Sachdev, P. S.
(author)
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Satizabal, C. L.
(author)
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Schmid, M.
(author)
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Scott, R. J.
(author)
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Scult, M. A.
(author)
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Simino, J.
(author)
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Slagboom, P. E.
(author)
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Smyrnis, N.
(author)
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Soumaré, A.
(author)
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Stefanis, N. C.
(author)
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Stott, D. J.
(author)
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Straub, R. E.
(author)
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Sundet, K.
(author)
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Taylor, A. M.
(author)
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Taylor, K. D.
(author)
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Tzoulaki, I.
(author)
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Tzourio, C.
(author)
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Uitterlinden, A.
(author)
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Vitart, V.
(author)
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Voineskos, A. N.
(author)
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Kaprio, J.
(author)
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Wagner, M.
(author)
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Wagner, H.
(author)
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Weinhold, L.
(author)
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Wen, K. H.
(author)
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Widen, E.
(author)
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Yang, Q.
(author)
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Zhao, W.
(author)
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Adams, H. H. H.
(author)
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Arking, D. E.
(author)
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Bilder, R. M.
(author)
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Bitsios, P.
(author)
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Boerwinkle, E.
(author)
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Chiba-Falek, O.
(author)
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Corvin, A.
(author)
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De Jager, P. L.
(author)
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Debette, S.
(author)
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Donohoe, G.
(author)
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Elliott, P.
(author)
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Fitzpatrick, A. L.
(author)
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Gill, M.
(author)
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Glahn, D. C.
(author)
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Hägg, S.Karolinska Institutet
(author)
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Hansell, N. K.
(author)
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Hariri, A. R.
(author)
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Ikram, M. K.
(author)
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Jukema, J. W.
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Vuoksimaa, E.
(author)
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Keller, M. C.
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Kremen, W. S.
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Launer, L.
(author)
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Lindenberger, U.
(author)
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Palotie, A.
(author)
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Pedersen, N. L.
(author)
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Pendleton, N.
(author)
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Porteous, D. J.
(author)
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Räikkönen, K.
(author)
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Raitakari, O. T.
(author)
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Ramirez, A.
(author)
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Reinvang, I.
(author)
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Rudan, I.
(author)
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Rujescu, D.
(author)
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Schmidt, R.
(author)
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Schmidt, H.
(author)
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Schofield, P. W.
(author)
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Schofield, P. R.
(author)
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Starr, J. M.
(author)
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Steen, V. M.
(author)
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Trollor, J. N.
(author)
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Turner, S. T.
(author)
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Van Duijn, C. M.
(author)
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Villringer, A.
(author)
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Weinberger, D. R.
(author)
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Weir, D. R.
(author)
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Wilson, J. F.
(author)
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Malhotra, A.
(author)
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McIntosh, A. M.
(author)
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Gale, C. R.
(author)
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Seshadri, S.
(author)
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Mosley, T.H., Jr.
(author)
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Bressler, J.
(author)
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Lencz, T.
(author)
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Deary, I. J.
(author)
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Karolinska InstitutetUmeå centrum för funktionell hjärnavbildning (UFBI)
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In:Nature Communications: Nature Publishing Group9:12041-1723
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Davies, G.
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Lam, M.
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Harris, S. E.
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Trampush, J. W.
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Luciano, M.
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Hill, W. D.
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Hagenaars, S. P.
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Ritchie, S. J.
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Marioni, R. E.
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Fawns-Ritchie, C ...
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Liewald, D. C. M ...
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Okely, J. A.
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Ahola-Olli, A. V ...
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Barnes, C. L. K.
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Bertram, L.
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Bis, J. C.
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Burdick, K. E.
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Christoforou, A.
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Derosse, P.
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Djurovic, S.
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Espeseth, T.
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Giakoumaki, S.
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Giddaluru, S.
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Gustavson, D. E.
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Hayward, C.
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Hofer, E.
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Ikram, M. A.
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Karlsson, R.
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Knowles, E.
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Lahti, J.
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Leber, M.
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Li, S.
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Mather, K. A.
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Melle, I.
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Morris, D.
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Oldmeadow, C.
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Palviainen, T.
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Payton, A.
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Pazoki, R.
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Petrovic, K.
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Reynolds, C. A.
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Sargurupremraj, ...
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Scholz, M.
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Smith, J. A.
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Smith, A. V.
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Amin, N.
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Böhmer, A. C.
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Campbell, H.
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Cannon, T. D.
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Cirulli, E. T.
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Congdon, E.
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Conley, E. D.
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Corley, J.
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Cox, S. R.
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Dale, A. M.
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Dehghan, A.
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Dick, D.
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Dickinson, D.
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Eriksson, J. G.
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Evangelou, E.
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Faul, J. D.
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Ford, I.
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Freimer, N. A.
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Gao, H.
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Giegling, I.
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Gillespie, N. A.
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Gordon, S. D.
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Gottesman, R. F.
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Griswold, M. E.
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Gudnason, V.
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Harris, T. B.
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Hartmann, A. M.
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Heiss, G.
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Holliday, E. G.
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Karlsson, Ida K.
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Knopman, D. S.
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Li, S. -C
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Scott, R. J.
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Simino, J.
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Stott, D. J.
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Straub, R. E.
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Taylor, A. M.
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Taylor, K. D.
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Tzoulaki, I.
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Uitterlinden, A.
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Widen, E.
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Yang, Q.
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Zhao, W.
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Adams, H. H. H.
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Arking, D. E.
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Bilder, R. M.
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Bitsios, P.
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Boerwinkle, E.
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Chiba-Falek, O.
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Corvin, A.
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De Jager, P. L.
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Gill, M.
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Glahn, D. C.
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Hägg, S.
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Hansell, N. K.
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Hariri, A. R.
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Ikram, M. K.
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Jukema, J. W.
-
Vuoksimaa, E.
-
Keller, M. C.
-
Kremen, W. S.
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Launer, L.
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Lindenberger, U.
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Palotie, A.
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Pedersen, N. L.
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Pendleton, N.
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Porteous, D. J.
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Räikkönen, K.
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Raitakari, O. T.
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Ramirez, A.
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Reinvang, I.
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Rudan, I.
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Rujescu, D.
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Schmidt, R.
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Schmidt, H.
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Schofield, P. W.
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Schofield, P. R.
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Starr, J. M.
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Steen, V. M.
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