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  • Davies, G. (author)

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-05-29
  • Nature Publishing Group,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:hj-41589
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-41589URI
  • https://doi.org/10.1038/s41467-018-04362-xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149020URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-157720URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138360071URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
  • General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

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  • Lam, M. (author)
  • Harris, S. E. (author)
  • Trampush, J. W. (author)
  • Luciano, M. (author)
  • Hill, W. D. (author)
  • Hagenaars, S. P. (author)
  • Ritchie, S. J. (author)
  • Marioni, R. E. (author)
  • Fawns-Ritchie, C. (author)
  • Liewald, D. C. M. (author)
  • Okely, J. A. (author)
  • Ahola-Olli, A. V. (author)
  • Barnes, C. L. K. (author)
  • Bertram, L. (author)
  • Bis, J. C. (author)
  • Burdick, K. E. (author)
  • Christoforou, A. (author)
  • Derosse, P. (author)
  • Djurovic, S. (author)
  • Espeseth, T. (author)
  • Giakoumaki, S. (author)
  • Giddaluru, S. (author)
  • Gustavson, D. E. (author)
  • Hayward, C. (author)
  • Hofer, E. (author)
  • Ikram, M. A. (author)
  • Karlsson, R.Karolinska Institutet (author)
  • Knowles, E. (author)
  • Lahti, J. (author)
  • Leber, M. (author)
  • Li, S. (author)
  • Mather, K. A. (author)
  • Melle, I. (author)
  • Morris, D. (author)
  • Oldmeadow, C. (author)
  • Palviainen, T. (author)
  • Payton, A. (author)
  • Pazoki, R. (author)
  • Petrovic, K. (author)
  • Reynolds, C. A. (author)
  • Sargurupremraj, M. (author)
  • Scholz, M. (author)
  • Smith, J. A. (author)
  • Smith, A. V. (author)
  • Terzikhan, N. (author)
  • Thalamuthu, A. (author)
  • Trompet, S. (author)
  • Van Der Lee, S. J. (author)
  • Ware, E. B. (author)
  • Windham, B. G. (author)
  • Wright, M. J. (author)
  • Yang, J. (author)
  • Yu, J. (author)
  • Ames, D. (author)
  • Amin, N. (author)
  • Amouyel, P. (author)
  • Andreassen, O. A. (author)
  • Armstrong, N. J. (author)
  • Assareh, A. A. (author)
  • Attia, J. R. (author)
  • Attix, D. (author)
  • Avramopoulos, D. (author)
  • Bennett, D. A. (author)
  • Böhmer, A. C. (author)
  • Boyle, P. A. (author)
  • Brodaty, H. (author)
  • Campbell, H. (author)
  • Cannon, T. D. (author)
  • Cirulli, E. T. (author)
  • Congdon, E. (author)
  • Conley, E. D. (author)
  • Corley, J. (author)
  • Cox, S. R. (author)
  • Dale, A. M. (author)
  • Dehghan, A. (author)
  • Dick, D. (author)
  • Dickinson, D. (author)
  • Eriksson, J. G. (author)
  • Evangelou, E. (author)
  • Faul, J. D. (author)
  • Ford, I. (author)
  • Freimer, N. A. (author)
  • Gao, H. (author)
  • Giegling, I. (author)
  • Gillespie, N. A. (author)
  • Gordon, S. D. (author)
  • Gottesman, R. F. (author)
  • Griswold, M. E. (author)
  • Gudnason, V. (author)
  • Harris, T. B. (author)
  • Hartmann, A. M. (author)
  • Hatzimanolis, A. (author)
  • Heiss, G. (author)
  • Holliday, E. G. (author)
  • Joshi, P. K. (author)
  • Kähönen, M. (author)
  • Kardia, S. L. R. (author)
  • Karlsson, Ida K.Karolinska Institutet(Swepub:hj)karida (author)
  • Kleineidam, L. (author)
  • Knopman, D. S. (author)
  • Kochan, N. A. (author)
  • Konte, B. (author)
  • Kwok, J. B. (author)
  • Le Hellard, S. (author)
  • Lee, T. (author)
  • Lehtimäki, T. (author)
  • Li, S. -C (author)
  • Liu, T. (author)
  • Koini, M. (author)
  • London, E. (author)
  • Longstreth, W.T., Jr. (author)
  • Lopez, O. L. (author)
  • Loukola, A. (author)
  • Luck, T. (author)
  • Lundervold, A. J. (author)
  • Lundquist, Anders,1978-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Statistik(Swepub:umu)anslst97 (author)
  • Lyytikäinen, L. -PKarolinska Institutet (author)
  • Martin, N. G. (author)
  • Montgomery, G. W. (author)
  • Murray, A. D. (author)
  • Need, A. C. (author)
  • Noordam, R. (author)
  • Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001 (author)
  • Ollier, W. (author)
  • Papenberg, G.Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Germany (author)
  • Pattie, A. (author)
  • Polasek, O. (author)
  • Poldrack, R. A. (author)
  • Psaty, B. M. (author)
  • Reppermund, S. (author)
  • Riedel-Heller, S. G. (author)
  • Rose, R. J. (author)
  • Rotter, J. I. (author)
  • Roussos, P. (author)
  • Rovio, S. P. (author)
  • Saba, Y. (author)
  • Sabb, F. W. (author)
  • Sachdev, P. S. (author)
  • Satizabal, C. L. (author)
  • Schmid, M. (author)
  • Scott, R. J. (author)
  • Scult, M. A. (author)
  • Simino, J. (author)
  • Slagboom, P. E. (author)
  • Smyrnis, N. (author)
  • Soumaré, A. (author)
  • Stefanis, N. C. (author)
  • Stott, D. J. (author)
  • Straub, R. E. (author)
  • Sundet, K. (author)
  • Taylor, A. M. (author)
  • Taylor, K. D. (author)
  • Tzoulaki, I. (author)
  • Tzourio, C. (author)
  • Uitterlinden, A. (author)
  • Vitart, V. (author)
  • Voineskos, A. N. (author)
  • Kaprio, J. (author)
  • Wagner, M. (author)
  • Wagner, H. (author)
  • Weinhold, L. (author)
  • Wen, K. H. (author)
  • Widen, E. (author)
  • Yang, Q. (author)
  • Zhao, W. (author)
  • Adams, H. H. H. (author)
  • Arking, D. E. (author)
  • Bilder, R. M. (author)
  • Bitsios, P. (author)
  • Boerwinkle, E. (author)
  • Chiba-Falek, O. (author)
  • Corvin, A. (author)
  • De Jager, P. L. (author)
  • Debette, S. (author)
  • Donohoe, G. (author)
  • Elliott, P. (author)
  • Fitzpatrick, A. L. (author)
  • Gill, M. (author)
  • Glahn, D. C. (author)
  • Hägg, S.Karolinska Institutet (author)
  • Hansell, N. K. (author)
  • Hariri, A. R. (author)
  • Ikram, M. K. (author)
  • Jukema, J. W. (author)
  • Vuoksimaa, E. (author)
  • Keller, M. C. (author)
  • Kremen, W. S. (author)
  • Launer, L. (author)
  • Lindenberger, U. (author)
  • Palotie, A. (author)
  • Pedersen, N. L. (author)
  • Pendleton, N. (author)
  • Porteous, D. J. (author)
  • Räikkönen, K. (author)
  • Raitakari, O. T. (author)
  • Ramirez, A. (author)
  • Reinvang, I. (author)
  • Rudan, I. (author)
  • Rujescu, D. (author)
  • Schmidt, R. (author)
  • Schmidt, H. (author)
  • Schofield, P. W. (author)
  • Schofield, P. R. (author)
  • Starr, J. M. (author)
  • Steen, V. M. (author)
  • Trollor, J. N. (author)
  • Turner, S. T. (author)
  • Van Duijn, C. M. (author)
  • Villringer, A. (author)
  • Weinberger, D. R. (author)
  • Weir, D. R. (author)
  • Wilson, J. F. (author)
  • Malhotra, A. (author)
  • McIntosh, A. M. (author)
  • Gale, C. R. (author)
  • Seshadri, S. (author)
  • Mosley, T.H., Jr. (author)
  • Bressler, J. (author)
  • Lencz, T. (author)
  • Deary, I. J. (author)
  • Karolinska InstitutetUmeå centrum för funktionell hjärnavbildning (UFBI) (creator_code:org_t)

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  • In:Nature Communications: Nature Publishing Group9:12041-1723

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