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Endocardial border ...
Endocardial border delineation capability of a multimodal polymer-shelled contrast agent
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- Larsson, Malin K. (författare)
- KTH Royal Institute of Technology, Stockholm, Sweden
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- Larsson, Matilda (författare)
- KTH Royal Institute of Technology, Stockholm, Sweden and Karolinska Institutet, Solna, Sweden
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- Nowak, Greg (författare)
- Karolinska Institutet, Stockholm, Sweden
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- Paradossi, Gaio (författare)
- Università di Roma Tor Vergata, Rome, Italy
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- Brodin, Lars-Åke (författare)
- KTH Royal Institute of Technology, Stockholm, Sweden and Karolinska Institutet, Solna, Sweden
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- Janerot Sjöberg, Birgitta (författare)
- KTH Royal Institute of Technology, Stockholm, Sweden and Karolinska Institutet, Solna, Sweden
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- Caidahl, Kenneth (författare)
- Karolinska Institutet, Solna, Sweden
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Bjällmark, Anna (författare)
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(creator_code:org_t)
- 2014
- 2014
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
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- BackgroundA novel polymer-shelled contrast agent (CA) with high mechanical and chemical stability was recently developed [1]. In excess to its ultrasound properties, it also supports targeted and multimodal imaging [2-4]. Even though these new possibilities have the potential to lead to new methodologies and approaches for non-invasive diagnosis, it is important that the fundamental diagnostic features in contrast-enhanced ultrasound are preserved. The aim of this study was therefore to examine the clinical use of the polymer-shelled CA by analyzing the left ventricular endocardial border delineation capability in a porcine model. In addition, physiological effects due to CA injections were studied.MethodsThe endocardial border delineation capability was assessed in a comparative study, which included three doses (1.5 ml, 3 ml and 5 ml, [5x108 MBs/ml]) of the polymer-shelled CA and the commercially available CA SonoVue® (1.5 ml, [2-5x108 MBs/ml]). Ultrasound images of the left ventricle were evaluated manually by blinded observers (n=3) according to a 6-segment model, in which each segment was graded as 0=not visible, 1=barely visible or 2=well visible, as well as semi-automatically by a segmentation software. Furthermore, duration of clinically useful contrast enhancement and changes in physiological parameters were evaluated.ResultsFor the highest dose of the polymer-shelled CA, the obtained segment scores, time for clinically sufficient contrast enhancement and semi-automatic delineation capability were comparable to SonoVue®. Moreover, neither dose of the polymer-shelled CA did affect the physiological parameters.ConclusionThis study demonstrated that the polymer-shelled CA can be used in contrast-enhanced diagnostic imaging without influence on major physiological parameters.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Publikations- och innehållstyp
- vet (ämneskategori)
- kon (ämneskategori)