Cigarette smoking affects microRNAs and inflammatory biomarkers in healthy individuals and an association to single nucleotide polymorphisms is indicated

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Andersson, Bengt-ÅkeLinköpings universitet,Jönköping University,HHJ. Biomedicinsk plattform,HHJ. Centrum för oral hälsa,Department of Laboratory Medicine, Ryhov County Hospital, Jönköping, Sweden,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Ryhov Cty Hosp, Sweden (author)

Cigarette smoking affects microRNAs and inflammatory biomarkers in healthy individuals and an association to single nucleotide polymorphisms is indicated

Article/chapterEnglish2019

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Taylor & Francis,2019
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LIBRIS-ID:oai:DiVA.org:hj-42387
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-42387URI
https://doi.org/10.1080/1354750X.2018.1539764DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-157272URI

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Language:English
Summary in:English

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Funding Agencies|Forskningsradet i Sydostra Sverige; Futurum-Academy of HealthCare at Jonkoping County Council [477461, 490031, 669631]; Foundation of Clinical Cancer Research in Jo nkoping [110426-1]; Medical Research Council of Southeast Sweden (FORSS) [567001]
BACKGROUND: Cigarette smoke induces inflammation and remodels immune response. Genetic and epigenetic alterations might be involved in the pathogenesis of smoking related diseases. In this study, we investigated the effect of smoking on systemic inflammation biomarkers and epigenetic changes at microRNA (miRNA) expression level. We also examined if the levels of inflammatory biomarkers were associated with selected single nucleotide polymorphisms (SNPs).METHOD: From 39 smokers and 101 non-smokers, levels of total white blood cells (WBCs) and its subpopulations, plasma cytokines/chemokines/proteins and miRNAs were analysed. For three biomarkers, C-reactive protein (CRP), MCP-1 and IFN-γ that were affected by smoking, the influence of SNPs was analyzed.RESULT: Elevated levels of total WBCs, neutrophils, monocytes, lymphocytes, CRP, MCP-1, IFN-γ and lower levels of miR-21 were detected in smokers. The elevated levels of IFN-γ in smokers was only statistically significantly associated with rs2069705 AG/GG SNP-genotype.CONCLUSIONS: A lower level of oncomir miRNA-21 and a higher level of immune modelling cytokine IFN-γ detected in smokers could be a protective immune response to cigarette smoke. The higher level of IFN-γ in smokers with a specific SNP genotype also suggests that a genetic interaction with smoking might predict the pathobiology of smoking related disease.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
Immune respons
cigarette smoking
microRNA
single nucleotide polymorphism
smoking related diseases

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Sayardoust, SharielDepartment of Periodontology, Institute for Postgraduate Dental Education, Jönköping, Sweden,Inst Postgrad Dent Educ, Sweden(Swepub:hj)saysha (author)
Löfgren, StureDepartment of Laboratory Medicine, Ryhov County Hospital, Jönköping, Sweden,Ryhov Cty Hosp, Sweden (author)
Rutqvist, Lars ErikScientific Affairs Group, Swedish Match AB, Stockholm, Sweden (author)
Lewin, NongnitLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Ryhov Cty Hosp, Sweden(Swepub:liu)nonle33 (author)
Jönköping UniversityHHJ. Biomedicinsk plattform (creator_code:org_t)

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In:Biomarkers: Taylor & Francis24:2, s. 180-1851354-750X1366-5804

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