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Possible role and t...
Possible role and therapeutic target of PDGF-D signalling in colorectal cancer
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- Slind Olsen, Renate (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Dept Lab Med, Sweden
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- Dimberg, Jan (author)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Jonkoping Univ, Sweden
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- Geffers, Robert (author)
- Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany,Helmholtz Ctr Infect Res, Germany
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- Wågsäter, Dick (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten
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(creator_code:org_t)
- 2019-03-05
- 2019
- English.
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In: Cancer Investigation. - : Taylor & Francis. - 0735-7907 .- 1532-4192. ; 37:2, s. 99-112
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Abstract
Subject headings
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- Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-β) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-β signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Angiogenesis
- Colorectal cancer
- Imatinib
- PDGF-D
- Proliferation
Publication and Content Type
- ref (subject category)
- art (subject category)
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