Health-related quality of life and medication adherence in elderly patients with epilepsy.

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Hamedi-Shahraki, SoudabehDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran (author)

Health-related quality of life and medication adherence in elderly patients with epilepsy.

Article/chapterEnglish2019

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Via Medica,2019
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LIBRIS-ID:oai:DiVA.org:hj-44034
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-44034URI
https://doi.org/10.5603/PJNNS.a2019.0008DOI

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Language:English
Summary in:English

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OBJECTIVE: Considering the high prevalence of epilepsy in the elderly and the importance of maximising their quality of life (QoL), this study aimed to investigate the relationship between medication adherence and QoL, and the mediating effects of medication adherence on the association between serum antiepileptic drug (AED) level and seizure severity with QoL in elderly epileptics.METHODS: In a longitudinal study, 766 elderly patients with epilepsy who were prescribed a minimum of one antiepileptic drug were selected by convenience sampling method. A Medication Adherence Report Scale (MARS-5) questionnaire was completed at the baseline. Seizure severity and QoL were assessed after six months using the Liverpool Seizure Severity Scale (LSSS) and the QoL in Epilepsy (QOLIE-31) questionnaires respectively. Serum level of AED was also measured at six-month follow-up.RESULTS: Medication adherence was significantly correlated with both seizure severity (β = -0.33, p < 0.0001) and serum AED level (β = 0.29, p < 0.0001) after adjusting for demographic and clinical characteristics. Neither QoL nor its sub-classes were correlated with seizure severity. In addition, a significant correlation was not observed between serum AED level and QoL. However, medication adherence was significantly correlated with QoL (β = 0.30, p < 0.0001). The mediating effects of medication adherence on the association between serum AED level (Z = 3.39, p < 0.001) and seizure severity (Z = -3.47, p < 0.001) with QoL were supported by the Sobel test.CONCLUSION: This study demonstrates that medication adherence has a beneficial impact on QoL in elderly epileptics. Therefore, adherence to treatment should be monitored to improve their QoL.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Samhällsfarmaci och klinisk farmaci hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Social and Clinical Pharmacy hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
elderly
epilepsy
medication adherence
quality of life
seizure

Added entries (persons, corporate bodies, meetings, titles ...)

Eshraghian, Mohammad-RezaDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran (author)
Yekaninejad, Mir-SaeedDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran (author)
Nikoobakht, MehdiDepartment of Neurosurgery, Iran University of Medical Sciences, Tehran (author)
Rasekhi, AliakbarDepartment of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran (author)
Chen, HuiSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia (author)
Pakpour, Amir H.Jönköping University,HHJ, Avdelningen för omvårdnad,Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran(Swepub:hj)pakami (author)
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, TehranDepartment of Neurosurgery, Iran University of Medical Sciences, Tehran (creator_code:org_t)

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In:Neurologia i Neurochirurgia Polska: Via Medica53:2, s. 123-1300028-38431897-4260

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