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Periodontal treatme...
Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis
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- Buhlin, K. (författare)
- Karolinska Institutet
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- Hultin, M. (författare)
- Karolinska Institutet
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- Norderyd, Ola (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Dept. of Periodontology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Dept. of Periodontology, Faculty of Odontology, Malmö University, Malmö, Sweden
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Persson, L. (författare)
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- Pockley, A. G. (författare)
- Karolinska Institutet
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Pussinen, P. J. (författare)
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Rabe, P. (författare)
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- Klinge, Björn (författare)
- Malmö högskola,Odontologiska fakulteten (OD)
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Gustafsson, A. (författare)
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(creator_code:org_t)
- Elsevier, 2009
- 2009
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 206:2, s. 518-522
- Relaterad länk:
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https://mau.diva-por...
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- This study investigated the effect of mechanical infection control for periodontitis and periodontal surgery on the prevalence of well-established risk factors for atherosclerosis, and plasma levels of cytokines, antibodies against heat shock proteins and markers of systemic inflammation. Sixty-eight patients between 39 and 73 years of age with severe periodontitis who had been referred to four specialist periodontology clinics in Sweden were investigated. A fasting venous blood sample was taken at baseline and additional samples were collected after 3 and 12 months. A total of 54 patients underwent periodontal treatment. The periodontal treatment was successful, as pathogenic gingival pockets decreased significantly. Plasma glucose, lipids and markers of systemic inflammation were not significantly altered after 3 months. One year after the initial treatment, HDL-C concentrations were significantly increased (Δ0.08 mmol/L) whereas LDL-C concentrations decreased (Δ0.23 mmol/L). Haptoglobin concentrations were also lower. Interleukin-18 and interferon-γ levels were also lower after 12 months (60 ng/L (-23%) and 11 ng/L (-97%) respectively). Treatment had no effect on plasma levels of IgA, IgG1, IgG2 antibodies against heat shock proteins. In conclusion, this study indicates that standard treatment for periodontal disease induces systemic changes in several biochemical markers that reflect the risk for atherosclerosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Atherosclerosis
- Inflammation
- Longitudinal study
- Periodontitis
- Risk factors
- Treatment
- biochemical marker
- cytokine
- gamma interferon
- glucose
- haptoglobin
- heat shock protein
- high density lipoprotein cholesterol
- immunoglobulin A antibody
- immunoglobulin antibody
- immunoglobulin G1 antibody
- immunoglobulin g2 antibody
- interleukin 18
- lipid
- low density lipoprotein cholesterol
- protein antibody
- unclassified drug
- adult
- aged
- article
- blood sampling
- cardiovascular risk
- controlled study
- female
- glucose blood level
- human
- infection control
- lipid blood level
- major clinical study
- male
- mouth hygiene
- periodontics
- priority journal
- protein blood level
- risk factor
- risk reduction
- Sweden
- tooth extraction
- venous blood
- Biological Markers
- Cholesterol
- HDL
- Cholesterol
- LDL
- Cytokines
- Humans
- Interferon-gamma
- Interleukin-18
- Lipids
- Middle Aged
- Smoking
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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