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- Malmström, Johan,1975Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials (author)
Bone response to free form-fabricated hydroxyapatite and zirconia scaffolds : A histological study in the human maxilla
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- John Wiley & Sons,2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:hj-53276
- https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53276URI
- https://doi.org/10.1111/j.1600-0501.2008.01595.xDOI
- https://gup.ub.gu.se/publication/126309URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-7045URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
Classification
Notes
- Objectives: Synthetic and biological materials are increasingly used to provide temporary or permanent scaffolds for bone regeneration. This study evaluated the effect of material chemistry and microporosity on bone ingrowth and osseointegration of zirconia (ZrO2) and hydroxyapatite (HA) scaffolds in the human maxilla.Material and methods: Twelve patients subjected to dental implant placement were enrolled in the study. Scaffolds of ZrO 2 and HA were placed in the maxilla of each subject, using a randomization protocol. After 3 months of healing, biopsies were harvested comprising the scaffolds and surrounding bone tissue. The biopsies were processed for histological evaluation and morphometric analysis (bone ingrowth and bone-to-scaffold contact).Results: Healing was uneventful in all cases. All scaffolds demonstrated a measurable bone response using light microscopy and scanning electron microscopy. Microporous HA scaffolds revealed four times larger bone ingrowth and seven times larger bone contact as compared with ZrO2 scaffolds.Conclusion: The results show that chemistry and microporosity of HA promote bone ingrowth and bone contact of ceramic scaffolds in human maxilla.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomaterialvetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomaterials Science hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- Bone regeneration
- Free form fabrication
- Human
- Hydroxyapatite
- Implant
- Microporosity
- Scaffolds
- Zirconia
- biomaterial
- tissue scaffold
- zirconium
- zirconium oxide
- adult
- aged
- article
- bone prosthesis
- chemistry
- clinical trial
- computer aided design
- controlled clinical trial
- controlled study
- drug effect
- jaw
- maxilla
- methodology
- middle aged
- nonparametric test
- physiology
- porosity
- randomized controlled trial
- tissue regeneration
- tooth implantation
- ultrastructure
- Alveolar Process
- Biocompatible Materials
- Bone Substitutes
- Computer-Aided Design
- Dental Implantation
- Endosseous
- Dental Implants
- Guided Tissue Regeneration
- Humans
- Hydroxyapatites
- Osseointegration
- Statistics
- Nonparametric
- Tissue Scaffolds
- Young Adult
- Adult
- Aged
- Alveolar Process
- drug effects
- physiology
- surgery
- ultrastructure
- Biocompatible Materials
- chemistry
- therapeutic use
- Bone Regeneration
- Bone Substitutes
- Computer-Aided Design
- Dental Implantation
- Endosseous
- methods
- Dental Implants
- Guided Tissue Regeneration
- Humans
- Hydroxyapatites
- Maxilla
- Middle Aged
- Osseointegration
- Porosity
- Statistics
- Nonparametric
- Tissue Scaffolds
- Young Adult
- Zirconium
Added entries (persons, corporate bodies, meetings, titles ...)
- Slotte, Christer,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xsloch (author)
- Adolfsson, E. (author)
- Norderyd, OlaMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odolno (author)
- Thomsen, Peter,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xthope (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap (creator_code:org_t)
Related titles
- In:Clinical Oral Implants Research: John Wiley & Sons20:4, s. 379-3850905-71611600-0501
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