Sökning: WFRF:(Rutqvist E.) >
Influence of single...
Influence of single nucleotide polymorphisms among cigarette smoking and non-smoking patients with coronary artery disease, urinary bladder cancer and lung cancer
-
- Lewin, N. L. (författare)
- Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
- Karlsson, Jan-Erik (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Ryhov Hosp, Sweden
-
- Robinsson, D. (författare)
- Ryhov Hosp, Sweden
-
visa fler...
-
- Fagerberg, M. (författare)
- Dept Urology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
- Kentsson, M. (författare)
- Dept of Internal Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
- Sayardoust, Shariel (författare)
- Dept Periodontology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
- Nilsson, Mats (författare)
- Linköpings universitet,Medicinska fakulteten,Institutionen för hälsa, medicin och vård,Academy of Health and Care, Region Jönköping, Jönköping, Sweden
-
- Shamoun, L. (författare)
- Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
- Andersson, B. -Å. (författare)
- Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
- Löfgren, S. (författare)
- Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
- Rutqvist, L. E. (författare)
- Scientific Affairs Group, Swedish Match AB, Stockholm, Sweden
-
- Lewin, F. (författare)
- Dept Oncology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2021-01-28
- 2021
- Engelska.
-
Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 16
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://journals.plo...
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction Cigarette smoke is suggested to be a risk factor for coronary artery disease (CAD), urinary bladder cancer (UBCa) or lung cancer (LCa). However, not all heavy smokers develop these diseases and elevated cancer risk among first-degree relatives suggests an important role of genetic factor. Methods Three hundred and ten healthy blood donors (controls), 98 CAD, 74 UBCa and 38 LCa patients were included in this pilot study. The influence of 92 single nucleotide polymorphisms (SNPs) and impact of cigarette smoking were analysed. Results Out of 92 SNPs tested, differences in distribution of 14 SNPs were detected between controls and patient groups. Only CTLA4 rs3087243 showed difference in both CAD and UBCa patient group compared to control group. Stratified by smoking status, the impact of smoking was associated to frequencies of 8, 3 and 4 SNPs in CAD, UBCa, LCa patients, respectively. None of these 92 SNPs showed a statistically significant difference to more than one type of disease among smoking patients. In non-smoking patients, 7, 3 and 6 SNPs were associated to CAD, UBCa, LCa, respectively. Out of these 92 SNPs, CTLA4 rs3087243 was associated to both non-smoking CAD and UBCa. The XRCC1 rs25487 was associated to both non-smoking UBCa and LCa. Conclusion SNPs might be important risk factors for CAD, UBCa and LCa. Distribution of the SNPs was specific for each patient group, not a random event. Impact of cigarette smoking on the disease was associated to the specific SNP sequences. Thus, smoking individuals with SNPs associated to risk of these serious diseases is an important target group for smoking cessation programs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cytotoxic T lymphocyte antigen 4
- DNA
- DNA repair protein XRCC1
- adult
- aged
- Article
- bladder cancer
- blood donor
- cancer risk
- cigarette smoking
- controlled study
- coronary artery disease
- CTLA4 gene
- female
- genetic association
- high risk population
- human
- lung cancer
- major clinical study
- male
- molecular pathology
- mutation rate
- non-smoker
- people by smoking status
- pilot study
- risk factor
- single nucleotide polymorphism
- smoking cessation program
- XRCC1 gene
- bladder tumor
- case control study
- genetic predisposition
- genetics
- lung tumor
- middle aged
- Case-Control Studies
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms
- Polymorphism
- Single Nucleotide
- Urinary Bladder Neoplasms
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
PLOS ONE
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Lewin, N. L.
-
Karlsson, Jan-Er ...
-
Robinsson, D.
-
Fagerberg, M.
-
Kentsson, M.
-
Sayardoust, Shar ...
-
visa fler...
-
Nilsson, Mats
-
Shamoun, L.
-
Andersson, B. -Å ...
-
Löfgren, S.
-
Rutqvist, L. E.
-
Lewin, F.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
PLOS ONE
- Av lärosätet
-
Jönköping University
-
Linköpings universitet