Sökning: L773:1095 6867 OR L773:0018 506X >
Maternal attenuatio...
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups
-
- Shionoya, Kiseko, 1964- (författare)
- Neurobehavioral Institute and Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA
-
- Moriceau, Stephanie (författare)
- Neurobehavioral Institute and Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA
-
- Bradstock, Peter (författare)
- Neurobehavioral Institute and Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA
-
visa fler...
-
- Sullivan, Regina M. (författare)
- Neurobehavioral Institute and Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2007
- 2007
- Engelska.
-
Ingår i: Hormones and Behavior. - : Elsevier. - 0018-506X .- 1095-6867. ; 52:3, s. 391-400
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Infant rats learn to prefer stimuli paired with pain, presumably due to the importance of learning to prefer the caregiver to receive protection and food. With maturity, a more ‘adult-like’ learning system emerges that includes the amygdala and avoidance/fear learning. The attachment and ‘adult-like’ systems appear to co-exist in older pups with maternal presence engaging the attachment system by lowering corticosterone (CORT). Specifically, odor–shock conditioning (11 odor–0.5 mA shock trials) in 12-day-old pups results in an odor aversion, although an odor preference is learned if the mother is present during conditioning. Here, we propose a mechanism to explain pups ability to ‘switch’ between the dual learning systems by exploring the effect of maternal presence on hypothalamic paraventricular nucleus (PVN) neural activity, norepinephrine (NE) levels and learning. Maternal presence attenuates both PVN neural activity and PVN NE levels during odor–shock conditioning. Intra-PVN NE receptor antagonist infusion blocked the odor aversion learning with maternal absence, while intra-PVN NE receptor agonist infusion permitted odor aversion learning with maternal presence. These data suggest maternal control over pup learning acts through attenuation of PVN NE to reduce the CORT required for pup odor aversion learning. Moreover, these data also represent pups’ continued maternal dependence for nursing, while enabling aversion learning outside the nest to prepare for pups future independent living.
Ämnesord
- NATURVETENSKAP -- Biologi -- Etologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Behavioural Sciences Biology (hsv//eng)
Nyckelord
- Corticosterone
- Attachment
- Fear conditioning
- Amygdala
- Infant
- Microdialysis
- Paraventricular nucleus
- Norepinephrine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas