Search: WFRF:(LUDVIGSSON J)
> (2020-2024) >
Prevalence and Impl...
Prevalence and Implications of Frailty in Older Adults With Incident Inflammatory Bowel Diseases : A Nationwide Cohort Study
-
- Kochar, Bharati (author)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Center for Aging and Serious Illness, Mongan Institute, Boston, Massachusetts, USA
-
- Jylhävä, Juulia (author)
- Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
-
- Söderling, Jonas (author)
- Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
-
show more...
-
- Ritchie, Christine S. (author)
- Harvard Medical School, Boston, Massachusetts, USA; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet Stockholm, Sweden; Center for Aging and Serious Illness, Mongan Institute, Boston, Massachusetts, USA
-
Olsson, M. (author)
-
Hjortswang, H. (author)
-
- Myrelid, Pär, 1970- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,SWIBREG Study Group
-
Bengtsson, J. (author)
-
Strid, H. (author)
-
Andersson, M. (author)
-
Jäghult, S. (author)
-
Eberhardson, M. (author)
-
Nordenvall, C. (author)
-
Björk, J. (author)
-
Fagerberg, U. L. (author)
-
- Rejler, Martin (author)
- Jönköping University,The Jönköping Academy for Improvement of Health and Welfare,Department of Medicine, Höglandssjukhuset Eksjö, Region Jönköping County Council, Jönköping, Sweden
-
Grip, O. (author)
-
Karling, P. (author)
-
Halfvarson, J. (author)
-
- Ludvigsson, J. F. (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
-
- Khalili, H. (author)
- Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Clinical Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
-
- Olén, O. (author)
- Karolinska Institutet,Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Pediatric Gastroenterology and Nutrition, Sachs' Children and Youth Hospital, Stockholm, Sweden; Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
-
Group, the SWIBREG Study (author)
-
show less...
-
(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
-
In: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 20:10, s. 2358-2365
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Background and Aims: We aimed to compare the risk of frailty in older adults with incident inflammatory bowel disease (IBD) and matched non-IBD comparators and assess the association between frailty and future hospitalizations and mortality.Methods: In a cohort of patients with incident IBD ≥60 years of age from 2007 to 2016 in Sweden identified using nationwide registers, we defined frailty using Hospital Frailty Risk Score. We compared prevalence of frailty in patients with IBD with age, sex, place of residency– and calendar year–matched population comparators. In the IBD cohort, we used Cox proportional hazards modeling to examine the associations between frailty risk and hospitalizations or mortality.Results: We identified 10,590 patients with IBD, 52% female with a mean age of 71 years of age, matched to 103,398 population-based comparators. Among patients with IBD, 39% had no risk for frailty, 49% had low risk for frailty, and 12% had higher risk for frailty. Mean Hospital Frailty Risk Score was 1.9 in IBD and 0.9 in matched comparators (P < .01). Older adults with IBD at higher risk for frailty had a 20% greater risk for mortality at 3 years compared with those who were not frail. Compared with nonfrail older patients with IBD, patients at higher risk for frailty had increased mortality (hazard ratio [HR], 3.22, 95% confidence interval [CI], 2.86–3.61), all-cause hospitalization (HR, 2.42; 95% CI, 2.24–2.61), and IBD-related hospitalization (HR, 1.50; 95% CI, 1.35–1.66). These associations were not attenuated after adjusting for comorbidities.Conclusions: Frailty is more prevalent in older adults with IBD than in matched comparators. Among older patients with IBD, frailty is associated with increased risk for hospitalizations and mortality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Aging
- Crohn's Disease
- Geriatric
- Ulcerative Colitis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Kochar, Bharati
-
Jylhävä, Juulia
-
Söderling, Jonas
-
Ritchie, Christi ...
-
Olsson, M.
-
Hjortswang, H.
-
show more...
-
Myrelid, Pär, 19 ...
-
Bengtsson, J.
-
Strid, H.
-
Andersson, M.
-
Jäghult, S.
-
Eberhardson, M.
-
Nordenvall, C.
-
Björk, J.
-
Fagerberg, U. L.
-
Rejler, Martin
-
Grip, O.
-
Karling, P.
-
Halfvarson, J.
-
Ludvigsson, J. F ...
-
Khalili, H.
-
Olén, O.
-
Group, the SWIBR ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Geriatrics
- Articles in the publication
-
Clinical Gastroe ...
- By the university
-
Jönköping University
-
Karolinska Institutet
-
Linköping University