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Sökning: L773:1423 0003 > The role of brain i...

  • Rydstrom, AndersStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Sweden,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden. (författare)

The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • S. Karger,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:hj-60483
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-60483URI
  • https://doi.org/10.1159/000530688DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-217338URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152608099URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction: Mechanisms underlying the positive association between occupational mental demands and late-life cognition are poorly understood. The objective of this study was to assess whether the association between occupational complexity and cognition is related to and moderated by brain integrity in individuals at-risk for dementia. Brain integrity was appraised throughout structural measures (Magnetic Resonance Imaging, MRI) and amyloid accumulation (Pittsburgh Compound B (PiB)-positron emission tomography, PiB-PET).Methods: Participants from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) neuroimaging sample -MRI (N=126), PiB-PET (N=41)- were included in a post-hoc cross-sectional analysis. Neuroimaging parameters comprised the Alzheimer ' s Disease signature cortical thickness (ADS, Freesurfer 5.3), medial temporal atrophy (MTA), and amyloid accumulation (PiB-PET). Cognition was assessed using the Neuropsychological Test Battery. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles. Linear regression models included cognition as dependent variable, occupational complexity, measures of brain integrity, and their interaction terms as predictors.Results: Occupational complexity with data and substantive complexity were associated with better cognition (overall cognition, executive function) when adjusting for ADS and MTA (independent association). Significant interaction effects between occupational complexity and brain integrity were also found, indicating that, for some indicators of brain integrity and cognition (e.g., overall cognition, processing speed), the positive association between occupational complexity and cognition occurred only among persons with higher brain integrity (moderated association).Conclusion: Among individuals at-risk for dementia, occupational complexity does not seem to contribute towards resilience against neuropathology. These exploratory findings require validation in larger populations.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stephen, RuthUniv Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland. (författare)
  • Kåreholt, Ingemar,1960-Stockholms universitet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden; Aging Research Center, Department of Neurobiology, Center for Alzheimer Research, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm, Sweden; Jönköping University, Jönköping, Sweden(Swepub:su)ikr (författare)
  • Mattsson, Alexander DarinKarolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden. (författare)
  • Ngandu, TiiaKarolinska Institutet (författare)
  • Lehtisalo, JenniUniv Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland.;Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Populat Hlth, Helsinki, Finland. (författare)
  • Backman, LarsStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden. (författare)
  • Kemppainen, NinaTurku Univ Hosp, Div Clin Neurosci, Turku, Finland.;Turku Univ Hosp, Turku PET Ctr, Turku, Finland. (författare)
  • Rinne, JuhaTurku Univ Hosp, Turku PET Ctr, Turku, Finland.;Univ Turku, InFLAMES Res Flagship Ctr, Turku, Finland. (författare)
  • Sindi, ShireenKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England. (författare)
  • Soininen, HilkkaUniv Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neuroctr Neurol, Kuopio, Finland. (författare)
  • Vanninen, RitvaKuopio Univ Hosp, Diagnost Imaging Ctr, Dept Clin Radiol, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med, Unit Radiol, Kuopio, Finland. (författare)
  • Solomon, AlinaKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland.;Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England. (författare)
  • Mangialasche, FrancescaStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden. (författare)
  • Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Gerontology: S. Karger69:8, s. 972-9850304-324X1423-0003

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