Cardiovascular effects of dobutamine stress testing in women with suspected coronary artery disease

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Blomstrand, PeterLinköping Heart Centre, University Hospital, Sweden (författare)

Cardiovascular effects of dobutamine stress testing in women with suspected coronary artery disease

Artikel/kapitelEngelska1996

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BMJ Publishing Group Ltd,1996
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LIBRIS-ID:oai:DiVA.org:hj-63330
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-63330URI
https://doi.org/10.1136/hrt.75.5.463DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Objective. To investigate the central and peripheral haemodynamic response to dobutamine stress testing in women with suspected ischaemic heart disease and to seek an explanation for the hypotension phenomenon. Design. 18 women aged 54-73 years were investigated with Doppler echocardiography and venous occlusion plethysmography during intravenous infusion of dobutamine 5-10 d after an episode of unstable angina. Results. An average peak dose of 33 (SD 9.7) μg/kg/min was given. Heart rate and cardiac output increased by 49% and 59%, respectively (P < 0.001). Total and leg peripheral vascular resistance decreased by 44% and 26%, respectively (P < 0.001). Four patients developed hypotension (decrease in systolic blood pressure > 10 mm Hg), one of whom had a paradoxical bradycardia and two a low increase in cardiac output. Patients with hypotension had a more pronounced decrease in total peripheral vascular resistance but a similar change in leg peripheral vascular resistance compared with patients without hypotension. Conclusions. Dobutamine infusion leads to marked peripheral vasodilatation and an increase in cardiac output. Some patients experience hypotension during the test for reasons which include paradoxical vasovagal reactions and diminished capacity for adequate increase in cardiac output. There is also a disparity between the pattern of total and leg peripheral vascular resistance in patients with hypotension which might reflect a baroreceptor mediated compensatory increase in vasoconstrictor tone of muscle vessels not matched in other vascular territories.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Dobutamine
Echocardiography
Plethysmography
Vascular resistance
adult
aged
article
clinical article
coronary artery disease
exercise
female
heart output
human
intravenous drug administration
pressoreceptor
priority journal
stress
vasodilatation

Biuppslag (personer, institutioner, konferenser, titlar ...)

Engvall, J.Linköping Heart Centre, University Hospital, Sweden (författare)
Swahn, E.Linköping Heart Centre, University Hospital, Sweden (författare)
Säfström, K.Linköping Heart Centre, University Hospital, Sweden (författare)
Thulesius, O.Linköping Heart Centre, University Hospital, Sweden (författare)
Wranne, B.Linköping Heart Centre, University Hospital, Sweden (författare)
Linköping Heart Centre, University Hospital, Sweden (creator_code:org_t)

Sammanhörande titlar

Ingår i:Heart: BMJ Publishing Group Ltd75:5, s. 463-4681355-60371468-201X

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Av författaren/redakt...: Blomstrand, Pete ...; Engvall, J.; Swahn, E.; Säfström, K.; Thulesius, O.; Wranne, B.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: Heart

Av lärosätet: Jönköping University

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