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Cortisol, cognition...
Cortisol, cognition and Alzheimer's disease biomarkers among memory clinic patients
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- Holleman, Jasper (författare)
- Karolinska Institutet
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- Adagunodo, Sofia (författare)
- Memory Clin Zent Schweiz, Luzerner Psychiat, Pfaffnau Sankt Urban, Switzerland.
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- Kåreholt, Ingemar, 1960- (författare)
- Karolinska Institutet,Stockholms universitet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Stockholm Univ, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Jönköping University, Sweden
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- Hagman, Goran (författare)
- Karolinska Institutet
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- Aspo, Malin (författare)
- Karolinska Institutet
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- Udeh-Momoh, Chinedu T. (författare)
- Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Imperial Coll London, Ageing Epidemiol Res Unit AGE, Sch Publ Hlth, Fac Med, London, England.
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- Solomon, Alina (författare)
- Karolinska Institutet
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- Kivipelto, Miia (författare)
- Karolinska Institutet
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- Sindi, Shireen (författare)
- Karolinska Institutet
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Karolinska Institutet Memory Clin Zent Schweiz, Luzerner Psychiat, Pfaffnau Sankt Urban, Switzerland (creator_code:org_t)
- 2022-10-19
- 2022
- Engelska.
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Ingår i: BMJ Neurology Open. - : BMJ Publishing Group Ltd. - 2632-6140. ; 4:2
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- ObjectiveThis study aims to investigate the relationship between diurnal cortisol patterns, cognition and Alzheimer's disease (AD) biomarkers in memory clinic patients.MethodMemory clinic patients were recruited from Karolinska University Hospital in Sweden (n=155). Diurnal cortisol patterns were assessed using five measures: awakening levels, cortisol awakening response, bedtime levels, the ratio of awakening to bedtime levels (AM/PM ratio) and total daily output. Cognition was measured in five domains: memory, working memory, processing speed, perceptual reasoning and overall cognition. AD biomarkers A beta(42), total tau and phosphorylated tau were assessed from cerebrospinal fluid (CSF). Cognition was measured at follow-up (average 32 months) in a subsample of participants (n=57).ResultsIn assessing the associations between cortisol and cognition, higher awakening cortisol levels were associated with greater processing speed at baseline. No relationship was found between diurnal cortisol patterns and change in cognition over time or CSF AD biomarkers in the total sample. After stratification by CSF A beta(42) levels, higher awakening cortisol levels were associated with worse memory performance in amyloid-positive participants. In amyloid-negative participants, higher bedtime cortisol levels and a lower AM/PM ratio were associated with lower overall cognition, greater awakening cortisol levels were associated with better processing speed, and a higher AM/PM ratio was associated with better perceptual reasoning. Additionally, higher awakening cortisol levels were associated with lower CSF A beta(42) levels in amyloid-positive participants, while higher bedtime cortisol levels and a lower AM/PM ratio were associated with higher CSF total tau in amyloid-negative participants.ConclusionsOur findings suggest that diurnal cortisol patterns are associated with cognitive function and provide new insights into the association between diurnal cortisol patterns and AD-related CSF biomarkers. Further research is needed to examine the complex relationship between cortisol, cognition and brain pathology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's Disease
- Stress
- Amyloid
- Cognition
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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