Novel biomarker profiles to improve individual diagnosis and prognosis in patients with suspected inflammatory bowel disease: protocol for the Nordic inception cohort study (NORDTREAT)

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: (WFRF:(Davidsdottir Loa)) > Novel biomarker pro...

Novel biomarker profiles to improve individual diagnosis and prognosis in patients with suspected inflammatory bowel disease : protocol for the Nordic inception cohort study (NORDTREAT)

Fejrskov, Anja (författare): Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark; Department of Internal Medicine, Molecular Diagnostics and Clinical Research Unit, Institute of Regional Health Research, University Hospital of Southern Denmark, Aabenraa, Denmark; Section for Biostatistics and Evidence-Based Research, Parker Institute, Frederiksberg, Denmark

Füchtbauer, Johannes David (författare): Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark; Research Unit of Medical Gastroenterology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Internal Medicine and Emergency Department, Odense University Hospital, Svendborg, Denmark

Davíðsdóttir, Lóa G (författare): Department of Gastroenterology, Landspitali National University Hospital of Iceland, Reykjavik, Iceland

visa fler...

Halfvarson, Jonas, 1970- (författare): Department of Internal Medicine, Örebro University Hospital, Örebro, Region Örebro län, Sweden

Høivik, Marte Lie (författare): Department of Gastroenterology, Oslo University Hospital, Oslo, Norway; University of Oslo Institute for Clinical Medicine, Oslo, Norway

Jensen, Michael Dam (författare): Department of Internal Medicine-Gastroenterology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark; Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

Mortensen, Joachim Høg (författare): Gastrointestinal Diseases, Nordic Bioscience A/S, Herlev, Denmark

Nielsen, Lene Nyholm (författare): Research Unit of Medical Gastroenterology and Hepatology, Hospital South West Jutland, Esbjerg, Denmark

Rejler, Martin (författare): Jönköping University,The Jönköping Academy for Improvement of Health and Welfare,Jönköping Academy for Improvement in Health and Welfare, Jönköping University, Jönköping, Sweden; Futurum-Academy for Healthcare, Futurum Academy of Health and Care, Jönköping, Region Jönköping County, Sweden

Repsilber, Dirk, 1971- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,School of Health and Medical Sciences, Örebro University, Örebro, Sweden

Söderholm, Johan D. (författare): Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Östergötland, Sweden

Aalykke, Claus (författare): Internal Medicine and Emergency Department, Odense University Hospital, Svendborg, Denmark

Andersen, Vibeke (författare): Department of Internal Medicine, Molecular Diagnostics and Clinical Research Unit, Institute of Regional Health Research, University Hospital of Southern Denmark, Aabenraa, Denmark; Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; OPEN, Open Patient data Explorative Network, University of Southern Denmark, Odense, Denmark

Christensen, Robin (författare): Section for Biostatistics and Evidence-Based Research, Parker Institute, Frederiksberg, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark

Kjeldsen, Jens (författare): Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark; Research Unit of Medical Gastroenterology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark

visa färre...

(creator_code:org_t)

BioMed Central (BMC), 2024
2024
Engelska.
Ingår i: BMJ Open. - : BioMed Central (BMC). - 2044-6055. ; 14:5

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://bmjopen.bmj....; https://urn.kb.se/re...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

INTRODUCTION: Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, can be challenging to diagnose, and treatment outcomes are difficult to predict. In the NORDTREAT cohort study, a Nordic prospective multicentre study, we aim to identify novel molecular biomarkers of diagnostic value by assessing the diagnostic test accuracy (cross-sectionally), as well as the prognostic utility when used as prognostic markers in the long-term (cohort study). In the diagnostic test accuracy study, the primary outcome is a successful diagnosis using one or more novel index tests at baseline compared with the ECCO criteria as the reference standard. The composite outcome of the prognostic utility study is 'severe IBD' within 52 weeks from inclusion, defined as one or more of the following three events: IBD-related surgery, IBD-related hospitalisation or IBD-related death.METHODS AND ANALYSIS: We aim to recruit 800 patients referred on suspicion of IBD to this longitudinal observational study, a collaboration between 11 inclusion sites in Denmark, Iceland, Norway and Sweden. Inclusion will occur from February 2022 until December 2023 with screening and baseline visits for all participants and three outcome visits at weeks 12, 26 and 52 after baseline for IBD-diagnosed patients. Biological material (blood, faeces, biopsies, urine and hair), clinical data and lifestyle information will be collected during these scheduled visits.ETHICS AND DISSEMINATION: This study will explore novel biomarkers to improve diagnostic accuracy and prediction of disease progression, thereby improving medical therapy and the quality of life for patients with IBD.The study is approved by the Ethics Committee (DK: S-20200051, v1.4, 16.10.2021; IS: VSNb2021070006/03.01, NO: 193064; SE: DNR 2021-05090) and the Danish Data Protecting Agency (20/54594). Results will be disseminated through peer-reviewed journals, patient associations and presentations at international conferences.CLINICAL TRIAL REGISTRATION NUMBER: NCT05414578; Pre-results.

Hitta via bibliotek

BMJ Open (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Fejrskov, Anja; Füchtbauer, Joha ...; Davíðsdóttir, Ló ...; Halfvarson, Jona ...; Høivik, Marte Li ...; Jensen, Michael ...; visa fler...; Mortensen, Joach ...; Nielsen, Lene Ny ...; Rejler, Martin; Repsilber, Dirk, ...; Söderholm, Johan ...; Aalykke, Claus; Andersen, Vibeke; Christensen, Rob ...; Kjeldsen, Jens; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Artiklar i publikationen: BMJ Open

Av lärosätet: Jönköping University; Örebro universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Novel biomarker profiles to improve individual diagnosis and prognosis in patients with suspected inflammatory bowel disease : protocol for the Nordic inception cohort study (NORDTREAT)

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub