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Experimental gingiv...
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Salvi, Giovanni E
(author)
Experimental gingivitis in type 1 diabetics : a controlled clinical and microbiological study.
- Article/chapterEnglish2005
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LIBRIS-ID:oai:DiVA.org:hkr-12263
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urn:nbn:se:hkr:diva-12263urn
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https://doi.org/10.1111/j.1600-051X.2005.00682.xDOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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OBJECTIVE: To monitor clinical and microbiological changes during experimental gingivitis in type 1 diabetics and non-diabetics.MATERIALS AND METHODS: Nine type 1 diabetics with good/moderate metabolic control and nine age-gender matched non-diabetics were recruited. Probing pocket depths in all subjects did not exceed 4 mm and none were affected by attachment loss. According to the original model, an experimental 3-week plaque accumulation resulting in experimental gingivitis development and a subsequent 2-week period of optimal plaque control were staged. Subgingival plaque samples were collected at days 0, 21 and 35 from one site per quadrant, pooled and analysed using checkerboard DNA-DNA hybridization.RESULTS: Diabetics (mean age 25.6+/-5.8 standard deviation (SD), range 16-35 years) had a mean HbA1c level of 8.1+/-0.7% (SD), while non-diabetics (mean age 24.8+/-5.7 (SD), range 15-36 years) were metabolically controlled (HbA1c< or =6.5%). Between Days 0, 21 and 35, no statistically significant differences in mean plaque and gingival index scores were observed between diabetics and non-diabetics. At days 7 and 21, however, diabetics showed statistically significantly higher percentages of sites with gingival index scores > or =2 compared with non-diabetics. Mean DNA probe counts of the red and orange complex species increased significantly (p<0.05) between days 0 and 21 and decreased significantly (p<0.05) between days 21 and 35 in both groups.CONCLUSION: Both diabetics and non-diabetics react to experimental plaque accumulation with gingival inflammation. Type 1 diabetics, however, develop an earlier and higher inflammatory response to a comparable bacterial challenge.
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Kandylaki, Maria
(author)
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Troendle, Amineh
(author)
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Persson, G. RutgerSchool of Dental Medicine, University of Berne(Swepub:hkr)peru
(author)
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Lang, Niklaus P
(author)
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School of Dental Medicine, University of Berne
(creator_code:org_t)
Related titles
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In:Journal of Clinical Periodontology32:3, s. 310-3160303-69791600-051X
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