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Adjunctive local an...
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Salvi, Giovanni ESchool of Dental Medicine, University of Berne, Berne, Switzerland
(author)
Adjunctive local antibiotic therapy in the treatment of peri-implantitis II : clinical and radiographic outcomes.
- Article/chapterEnglish2007
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LIBRIS-ID:oai:DiVA.org:hkr-12272
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urn:nbn:se:hkr:diva-12272urn
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https://doi.org/10.1111/j.1600-0501.2007.01377.xDOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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AIM: To monitor over 12 months clinical and radiographic changes occurring after adjunctive local delivery of minocycline microspheres for the treatment of peri-implantitis.MATERIAL AND METHODS: In 25 partially edentulous subjects, 31 implants diagnosed with peri-implantitis were treated. Three weeks after oral hygiene instruction, mechanical debridement and local antiseptic cleansing using 0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline microspheres (Arestin) were locally delivered to each implant site with bone loss and a probing pocket depth (PPD) >or=5 mm. Rescue therapy with Arestin was allowed at Days 180 and 270 at any site exhibiting an increase in PPD>or=2 mm from the previous visit. The following clinical parameters were recorded at four sites/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI).RESULTS: Six implants in six subjects were either rescued or exited because of persisting active peri-implantitis. Successful implants showed a statistically significant reduction in both PPD and percentage of sites with BOP between baseline and Day 360 (P<0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6 mm (95% CI: 0.9-2.2 mm, P<0.001) and was accompanied by a statistically significant reduction of the BOP value (P<0.001). Binary regression analysis showed that the clinical parameters and smoking history could not discriminate between successfully treated and rescued or exited implants at any observation time point.CONCLUSION: Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months.
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Persson, G. RutgerSchool of Dental Medicine, University of Berne, Berne, Switzerland(Swepub:hkr)peru
(author)
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Heitz-Mayfield, Lisa J AUniversity of Western Australia, Perth, Australia
(author)
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Frei, MarcSchool of Dental Medicine, University of Berne, Berne, Switzerland
(author)
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Lang, Niklaus PSchool of Dental Medicine, University of Berne, Berne, Switzerland
(author)
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School of Dental Medicine, University of Berne, Berne, SwitzerlandUniversity of Western Australia, Perth, Australia
(creator_code:org_t)
Related titles
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In:Clinical Oral Implants Research18:3, s. 281-2850905-71611600-0501
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