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High-sensitivity se...
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Persson, G. RutgerDepartments of Periodontics and Oral Medicine, University of Washington, Seattle, WA, USA & Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Bern, Bern, Switzerland,Departments of Periodontics and Oral Medicine, University of Washington, Seattle, WA, USA & Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Bern, Bern, Switzerland
(author)
High-sensitivity serum C-reactive protein levels in subjects with or without myocardial infarction or periodontitis.
- Article/chapterEnglish2005
Publisher, publication year, extent ...
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Blackwell Munksgaard,2005
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5
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LIBRIS-ID:oai:researchportal.hkr.se/admin:publications/9eea2fc1-2aa6-4071-9c8d-31800ccabd3f
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oai:researchportal.hkr.se/admin:publications/9eea2fc1-2aa6-4071-9c8d-31800ccabd3fURI
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https://doi.org/10.1111/j.1600-051X.2005.00648.xDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Serum high-sensitivity C-reactive protein (hsC-rp) is a non-specific marker of inflammation. Elevated hsC-rp levels are found in subjects with cardiovascular diseases (CVDs). Periodontitis may influence hsC-rp levels. OBJECTIVES: To assess periodontal status and hsC-rp serum levels in consecutive subjects hospitalized and diagnosed with acute myocardial infarction (AMI) (n=85) and in a group of carefully matched subjects (gender, age social, ethnic, and smoking habits) without clinical evidence of CVD (n=63). METHODS: hsC-rp levels, other routine serum values, and clinical periodontal conditions were studied. RESULTS: Subjects with AMI had higher hsC-rp levels than control subjects (p<0.001, Mann-Whitney U-test). The odds that subjects in the control group with periodontitis (30% or more sites with>4.0 mm loss of alveolar bone) had serum hsC-rp>1.8 mg/l was 1.5 (95% CI: 1.1-7.3, p<0.05). Stepwise linear regression analysis failed to include periodontal parameters in an explanatory model to hsC-rp values. Only the serum leucocyte (white blood cell (WBC)) counts were explanatory to hsC-rp values (beta standard coefficient=0.45, t=3.2, p<0.001). Serum WBC counts were significantly higher in control subjects with periodontitis (p<0.03) but not in subjects in the AMI group (p<0.57). CONCLUSIONS: (1) As expected, elevated serum hsC-rp concentration and serum WBC counts are associated with acute coronary heart disease. (2) Elevated serum hsC-rp values are associated with radiographically defined periodontitis in subjects with no evidence of CVD. (3) Periodontal parameters are not explanatory to elevated serum hsC-rp values if serum WBC and low-density lipoprotein counts are included in the regression model.
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Pettersson, ThomasKristianstad Hospital,Centralsjukhuset Kristianstad
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Ohlsson, Ola
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Renvert, StefanKristianstad University(Swepub:hkr)10896a6c-95b9-43c1-9cbc-8ca94700e206
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Departments of Periodontics and Oral Medicine, University of Washington, Seattle, WA, USA & Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Bern, Bern, SwitzerlandKristianstad Hospital
(creator_code:org_t)
Related titles
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In:Journal of Clinical Periodontology: Blackwell Munksgaard32:3, s. 219-2240303-69791600-051X
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