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  • Kanatsuna, Norio (author)

Autoimmunity against INS-IGF2 Protein Expressed in Human Pancreatic Islets

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:hkr-12676
  • urn:nbn:se:hkr:diva-12676urn
  • https://doi.org/10.1074/jbc.M113.478222DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • gratis
  • Insulin is a major autoantigen in islet autoimmunity and progression to type 1 diabetes. It has been suggested that the insulin B-chain may be critical to insulin autoimmunity in type 1 diabetes. INS-IGF2 consists of the preproinsulin signal peptide, the insulin B-chain, and eight amino acids of the C-peptide in addition to 138 amino acids from the IGF2 gene. We aimed to determine the expression of INS-IGF2 in human pancreatic islets and autoantibodies in newly diagnosed children with type 1 diabetes and controls. INS-IGF2, expressed primarily in beta cells, showed higher levels of expression in islets from normal compared with donors with either type 2 diabetes (p = 0.006) or high HbA1c levels (p < 0.001). INS-IGF2 autoantibody levels were increased in newly diagnosed patients with type 1 diabetes (n = 304) compared with healthy controls (n = 355; p < 0.001). Displacement with cold insulin and INS-IGF2 revealed that more patients than controls had doubly reactive insulin-INS-IGF2 autoantibodies. These data suggest that INS-IGF2, which contains the preproinsulin signal peptide, the B-chain, and eight amino acids of the C-peptide may be an autoantigen in type 1 diabetes. INS-IGF2 and insulin may share autoantibody-binding sites, thus complicating the notion that insulin is the primary autoantigen in type 1 diabetes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Taneera, Jalal (author)
  • Vaziri-Sani, FaribaLund University(Swepub:hkr)vazfar (author)
  • Wierup, Nils (author)
  • Larsson, Helena Elding (author)
  • Delli, Ahmed (author)
  • Skarstrand, Hanna (author)
  • Balhuizen, Alexander (author)
  • Bennet, Hedvig (author)
  • Steiner, Donald F. (author)
  • Torn, Carina (author)
  • Fex, Malin (author)
  • Lernmark, Ake (author)
  • Lund University (creator_code:org_t)

Related titles

  • In:Journal of Biological Chemistry288:40, s. 29013-290230021-92581083-351X

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