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Doubly reactive INS...
Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes
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- Kanatsuna, N (author)
- Lund University
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- Delli, A (author)
- Lund University
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- Andersson, C (author)
- Lund University
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show more...
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- Nilsson, A-L (author)
- Lund University
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- Vaziri-Sani, Fariba (author)
- Lund University
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- Larsson, K (author)
- Kristianstad Hospital
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- Carlsson, A (author)
- Lund University
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- Cedervall, E (author)
- Ängelholm Hospital
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- Jönsson, B (author)
- Ystad Hospital
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- Neiderud, J (author)
- Helsingborg Hospital
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- Elding Larsson, H (author)
- Lund University
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- Ivarsson, S-A (author)
- Lund University
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- Törn, C (author)
- Lund University
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- Fex, M (author)
- Lund University
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- Lernmark, Å (author)
- Lund University
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- Nilsson, Anna-Lena (author)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
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- Vaziri Sani, Fariba (author)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
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Cedervall, Elisabeth (author)
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- Törn, Carina (author)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
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- Neiderud, Jan (author)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Jönsson, Björn (author)
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- Larsson, Helena (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Andersson, Cecilia K (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Kanatsuna, Norio (author)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
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- Delli, Ahmed (author)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
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- Larsson, Karin (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Carlsson, Annelie (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Fex, Malin (author)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
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- Ivarsson, Sten (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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(creator_code:org_t)
- Wiley-Blackwell, 2015
- 2015
- English.
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In: Scandinavian Journal of Immunology. - : Wiley-Blackwell. - 0300-9475 .- 1365-3083. ; 82:4, s. 361-369
- Related links:
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https://doi.org/10.1...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim of this study was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ or both, in patients and controls with newly diagnosed type 1 diabetes. Patients (n = 676), 0-18 years of age, diagnosed with type 1 diabetes in 1996-2005 and controls (n = 363) were analysed for specific INS-IGF2A after displacement with both cold insulin and INS-IGF2 to correct for non-specific binding and identify double reactive sera. GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, ZnT8QA and HLA-DQ genotypes were also determined. The median level of specific INS-IGF2A was higher in patients than in controls (P < 0.001). Irrespective of age at diagnosis, 19% (126/676) of the patients had INS-IGF2A when the cut-off was the 95th percentile of the controls (P < 0.001). The risk of INS-IGF2A was increased among HLA-DQ2/8 (OR = 1.509; 95th CI 1.011, 2.252; P = 0.045) but not in 2/2, 2/X, 8/8, 8/X or X/X (X is neither 2 nor 8) patients. The association with HLA-DQ2/8 suggests that this autoantigen may be presented on HLA-DQ trans-heterodimers, rather than cis-heterodimers. Autoantibodies reactive with both insulin and INS-IGF2A at diagnosis support the notion that INS-IGF2 autoimmunity contributes to type 1 diabetes.
Subject headings
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Insulin antibodies
- mellitus
- risk
- assay
- antibodies
- beta
- specificity
- prevalence
- appearance
- epitope
Publication and Content Type
- ref (subject category)
- art (subject category)
- By the author/editor
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Kanatsuna, N
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Delli, A
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Andersson, C
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Nilsson, A-L
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Vaziri-Sani, Far ...
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Larsson, K
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show more...
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Carlsson, A
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Cedervall, E
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Jönsson, B
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Neiderud, J
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Elding Larsson, ...
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Ivarsson, S-A
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Törn, C
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Fex, M
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Lernmark, Å
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Nilsson, Anna-Le ...
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Cedervall, Elisa ...
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Törn, Carina
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Neiderud, Jan
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Jönsson, Björn
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Larsson, Helena
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Andersson, Cecil ...
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Kanatsuna, Norio
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Delli, Ahmed
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Larsson, Karin
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Carlsson, Anneli ...
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Fex, Malin
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Lernmark, Åke
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Ivarsson, Sten
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Kristianstad University College
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Lund University