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  • Kanatsuna, NLund University (author)

Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Wiley-Blackwell,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:hkr-15865
  • urn:nbn:se:hkr:diva-15865urn
  • https://doi.org/10.1111/sji.12325DOI
  • https://lup.lub.lu.se/record/7486352URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • gratis
  • The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim of this study was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ or both, in patients and controls with newly diagnosed type 1 diabetes. Patients (n = 676), 0-18 years of age, diagnosed with type 1 diabetes in 1996-2005 and controls (n = 363) were analysed for specific INS-IGF2A after displacement with both cold insulin and INS-IGF2 to correct for non-specific binding and identify double reactive sera. GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, ZnT8QA and HLA-DQ genotypes were also determined. The median level of specific INS-IGF2A was higher in patients than in controls (P < 0.001). Irrespective of age at diagnosis, 19% (126/676) of the patients had INS-IGF2A when the cut-off was the 95th percentile of the controls (P < 0.001). The risk of INS-IGF2A was increased among HLA-DQ2/8 (OR = 1.509; 95th CI 1.011, 2.252; P = 0.045) but not in 2/2, 2/X, 8/8, 8/X or X/X (X is neither 2 nor 8) patients. The association with HLA-DQ2/8 suggests that this autoantigen may be presented on HLA-DQ trans-heterodimers, rather than cis-heterodimers. Autoantibodies reactive with both insulin and INS-IGF2A at diagnosis support the notion that INS-IGF2 autoimmunity contributes to type 1 diabetes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Delli, ALund University (author)
  • Andersson, CLund University (author)
  • Nilsson, A-LLund University (author)
  • Vaziri-Sani, FaribaLund University(Swepub:hkr)vazfar (author)
  • Larsson, KKristianstad Hospital (author)
  • Carlsson, ALund University (author)
  • Cedervall, EÄngelholm Hospital (author)
  • Jönsson, BYstad Hospital (author)
  • Neiderud, JHelsingborg Hospital (author)
  • Elding Larsson, HLund University (author)
  • Ivarsson, S-ALund University (author)
  • Törn, CLund University (author)
  • Fex, MLund University (author)
  • Lernmark, ÅLund University (author)
  • Nilsson, Anna-LenaLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)med-a-n (author)
  • Vaziri Sani, FaribaLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)fa3255va (author)
  • Cedervall, Elisabeth (author)
  • Törn, CarinaLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)med-cto (author)
  • Neiderud, JanLund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-jnu (author)
  • Jönsson, Björn (author)
  • Larsson, HelenaLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)pedi-hla (author)
  • Andersson, Cecilia KLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)med-cao (author)
  • Kanatsuna, NorioLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)med-nku (author)
  • Delli, AhmedLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)med-add (author)
  • Larsson, KarinLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)med-kil (author)
  • Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-acs (author)
  • Fex, MalinLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)medk-mf0 (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)endo-ale (author)
  • Ivarsson, StenLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)pedi-siv (author)
  • Lund UniversityKristianstad Hospital (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Immunology: Wiley-Blackwell82:4, s. 361-3690300-94751365-3083

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