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Higher intensity of...
Higher intensity of Low Molecular Weight Protein Tyrosine Phosphatase/ ACP-1 in survivors of patients diagnosed with Diffuse Large B Cell Lymphoma (DLBCL) compared to non-survivors
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- Stanezai, S. (author)
- Malmö University
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- Sahlen, E. (author)
- Malmö University
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El-Schich, Z. (author)
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- Fridberg, Marie, 1972- (author)
- Högskolan Kristianstad,Forskningsmiljön Learning in Science and Mathematics (LISMA),Avdelningen för Naturvetenskap,LISMA
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- Fredriksson, G. N. (author)
- Lund University
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- Anagnostaki, L. (author)
- Skåne University Hospital
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- Tassidis, Helena (author)
- Malmö högskola,Högskolan Kristianstad,Avdelningen för Naturvetenskap,Forskningsmiljön Man & Biosphere Health (MABH),Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Persson, L. (author)
- Lund University
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- Gjorloff Wingren, Anette (author)
- Malmö University
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- El-Schich, Zahra (author)
- Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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Sahlén, Elisabeth (author)
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Stanezai, Sanga (author)
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Persson, Jenny L (author)
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- Gjörloff Wingren, Anette (author)
- Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Nordin Fredrikson, Gunilla (author)
- Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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Anagnostaki, Lola (author)
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(creator_code:org_t)
- Austin Publishing, 2016
- 2016
- English.
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In: Austin Biology. - : Austin Publishing. ; 1:2
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http://austinpublish...
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http://hkr.diva-port... (primary) (Raw object)
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Abstract
Subject headings
Close
- Adult Diffuse Large B Cell Lymphoma (DLBCL) is a heterogeneous form of hematopoietic cancer and difficult to treat. In order to find a better diagnostic indication for the disease, we analyzed Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP) that in humans is encoded by the ACP1 gene. LMWPTP is an enzyme shown to counteract Protein Tyrosine Kinases (PTK) and was suggested to be a negative growth factor regulator. However, the 18 kDa PTP can also have a positive effect on cell growth and proliferation, indicating a controversial role in the tumorigenic process. LMWPTP exists in different isoforms which are electrophoretically, kinetically and immunologically distinct. We have studied two subgroups of DLBCL consisting of a Germinal Center B cell like (GCB) and a non-Germinal Center B cell like (non-GCB) group. The two subgroups have been defined by gene-expressing profiling and are associated with differential outcome. The expression levels of LMWPTP protein was compared and showed significant differences between the GCB and non- GCB subgroups (p=0.012). Interestingly, when the samples were divided into survivors and non-survivors, and thereafter analyzed for LMWPTP expression, the samples from patients with a higher survival rate showed increased staining intensity, whereas the samples from patients with lower intensity of LMWPTP did not survive the disease (p=0.001). In conclusion, we have shown that DLBCL patients with worse outcome express LMWPTP with a lower intensity, suggesting a tumor suppressor role for this form of the enzyme.
Subject headings
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
Keyword
- ACP1
- B cell
- DLBCL
- Germinal center
- LMWPTP
- Lymphoma
- Non-germinal center
- Prognosis
- B-cell
- germinal center
- lymphoma
- non-germinal center
- prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
- By the author/editor
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Stanezai, S.
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Sahlen, E.
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El-Schich, Z.
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Fridberg, Marie, ...
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Fredriksson, G. ...
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Anagnostaki, L.
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show more...
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Tassidis, Helena
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Persson, L.
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Gjorloff Wingren ...
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El-Schich, Zahra
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Sahlén, Elisabet ...
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Stanezai, Sanga
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Persson, Jenny L
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Gjörloff Wingren ...
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Nordin Fredrikso ...
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Anagnostaki, Lol ...
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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and Medical Bioscien ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
- Articles in the publication
- Austin Biology
- By the university
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Kristianstad University College
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Malmö University