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Prominent binding o...
Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat
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- Hillefors, M. (författare)
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- von Euler, Mia, 1967- (författare)
- Karolinska Institutet
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- Hedlund, P. B. (författare)
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- von Euler, G. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 1999
- 1999
- Engelska.
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Ingår i: Brain Research. - : Elsevier. - 0006-8993 .- 1872-6240. ; 822:1-2, s. 126-131
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We have analyzed the binding properties of the selective D3 receptor agonist [3H]PD 128907 in 120 days old rats. In tissue sections, we found high numbers of binding sites for [3H]PD 128907 both in the islands of Calleja and the caudate-putamen (Bmax values being 500 and 1000 fmol/mg protein, respectively). The KD values were higher in the caudate-putamen than in the islands of Calleja. Similar regional differences in Bmax and KD values were observed in membranes from the caudate-putamen and the subcortical limbic region. The distribution of [3H]PD 128907 in adult rats is markedly different from that observed in young rats. Taken together, the present results suggest a prominent presence of D3 receptors in the caudate-putamen of adult, but not young, rats. Hence, these findings may have important physiological, pathophysiological, and clinical implications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- PD 128907
- Dopamine D3 receptor
- Binding affinity
- Basal ganglia
- Caudate–putamen
- Islands of Calleja
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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