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Restitution of neur...
Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men
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- Lindgren, M. (author)
- Department of Clinical Neurophysiology, Lund University and University Hospital
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- Eckert, B. (author)
- Department of Internal Medicine, Lund University and University Hospital
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- Stenberg, Georg, 1947- (author)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Agardh, C. D. (author)
- Department of Internal Medicine, Lund University and University Hospital
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- Agardh, Carl-David (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Lindgren, M (author)
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Eckert, B (author)
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(creator_code:org_t)
- Wiley-Blackwell, 1996
- 1996
- English.
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In: Diabetic Medicine. - : Wiley-Blackwell. - 0742-3071 .- 1464-5491. ; 13:3, s. 218-25
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast.
Subject headings
- SOCIAL SCIENCES -- Psychology -- Psychology (excluding Applied Psychology) (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (exklusive tillämpad psykologi) (hsv//swe)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Adult
- Analysis of Variance
- Blood Glucose/drug effects/metabolism
- Cognition/*drug effects
- Comparative Study
- Electroencephalography/*drug effects
- Epinephrine/*blood
- Evoked Potentials
- Auditory/drug effects
- Evoked Potentials
- Visual/drug effects
- Human
- Hypoglycemia/blood/chemically induced/*physiopathology
- *Insulin/administration & dosage/pharmacology
- Male
- Reaction Time/drug effects
- Reference Values
- Single-Blind Method
- Support
- Non-U.S. Gov't
- Cognitive science
- Kognitionsforskning
- SOCIAL SCIENCES
- SAMHÄLLSVETENSKAP
- Hypoglycaemia Cognitive Function
Publication and Content Type
- ref (subject category)
- art (subject category)