Porosity distribution affecting mechanical and biological behaviour of hydroxyapatite bioceramic composites

Kanhed, SatishLaboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India (author)

Funders: Ministry of Human Rersource Development, Government of India
The present work aims to the study of developing porosity in hydroxyapatite (HAp) scaffold by using graphite porogen (with 0-30 vol%) followed by engineering the changes achieved by conventional- (CS) and microwave sintering (MS) techniques. The generated porosity was controlled between similar to 6-27% as the porogen concentration increases in HAp scaffold. Voronoi tessellation was utilized in order to evaluate the distribution of pores. The enhanced mechanical properties including fracture toughness (0.83 MPa m(1/2)), fracture strength (7.5 MPa), and hardness (183.7 VHN) were observed for microwave sintered HAp scaffold with 8% porosity. The fitting between porosity and fracture strength elicited that microwave sintered HAp with 8% porosity provides maximum crack-propagation resistance while restricting grain size (similar to 0.23 mu m) and eliciting high extent of sintering (similar to 1.34) because of their rapid heating rates. The cell viability (MTT assay) and cell culture confirm the cytocompatibility of porous HAp for application as bone implant that need accelerated replacement of bone tissues.

TEKNIK OCH TEKNOLOGIER Materialteknik Bearbetnings-, yt- och fogningsteknik hsv//swe
ENGINEERING AND TECHNOLOGY Materials Engineering Manufacturing, Surface and Joining Technology hsv//eng
Hydroxyapatite; Porosity; Voronoi tessellation; Mechanical property; Cytocompatibility
Manufacturing and materials engineering
Produktions- och materialteknik

Awasthi, ShikhaLaboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India (author)
Goel, Sneha,1993-Högskolan Väst,Avdelningen för avverkande och additativa tillverkningsprocesser (AAT),PTW(Swepub:hv)sngo0001 (author)
Pandey, AditiLaboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India (author)
Sharma, RajeevLaboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India (author)
Upadhyaya, AnishPowder Metallurgy Laboratory, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India (author)
Balani, KanteshLaboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India (author)
Laboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, IndiaAvdelningen för avverkande och additativa tillverkningsprocesser (AAT) (creator_code:org_t)

By the author/editor: Kanhed, Satish; Awasthi, Shikha; Goel, Sneha, 199 ...; Pandey, Aditi; Sharma, Rajeev; Upadhyaya, Anish; show more...; Balani, Kantesh; show less...

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Materials Engine ...; and Manufacturing Su ...

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