Sökning: WFRF:(Shao Hui)
> (2020-2024) >
Prognostic implicat...
Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC) : a multicentre, multinational, individual patient data analysis
-
- Mehanna, Hisham (författare)
- Univ Birmingham, Inst Head Neck Studies & Educ InHANSE, Inst Canc & Genom Sci, Birmingham, England.;Univ Birmingham, Inst Head Neck Studies & Educ InHANSE, Inst Canc & Genom Sci, Birmingham B15 2TT, England.
-
- Taberna, Miren (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Dept Med Oncol, Barcelona, Spain.;Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Barcelona, Spain.;Univ Barcelona, Dept Med, Barcelona, Spain.
-
- von Buchwald, Christian (författare)
- Copenhagen Univ Hosp, Dept Otolaryngol Head & Neck Surg & Audiol, Rigshosp, Copenhagen, Denmark.
-
visa fler...
-
- Tous, Sara (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Barcelona, Spain.;Inst Salud Carlos III, Epidemiol & Publ Hlth, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid, Spain.
-
- Brooks, Jill (författare)
- Univ Birmingham, Inst Head Neck Studies & Educ InHANSE, Inst Canc & Genom Sci, Birmingham, England.
-
- Mena, Marisa (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Barcelona, Spain.;Inst Salud Carlos III, Epidemiol & Publ Hlth, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid, Spain.
-
- Morey, Francisca (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Barcelona, Spain.
-
- Gronhoj, Christian (författare)
- Copenhagen Univ Hosp, Dept Otolaryngol Head & Neck Surg & Audiol, Rigshosp, Copenhagen, Denmark.
-
- Rasmussen, Jacob Hoygaard (författare)
- Copenhagen Univ Hosp, Dept Otolaryngol Head & Neck Surg & Audiol, Rigshosp, Copenhagen, Denmark.
-
- Garset-Zamani, Martin (författare)
- Copenhagen Univ Hosp, Dept Otolaryngol Head & Neck Surg & Audiol, Rigshosp, Copenhagen, Denmark.
-
- Bruni, Laia (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Barcelona, Spain.;Inst Salud Carlos III, Epidemiol & Publ Hlth, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid, Spain.
-
- Batis, Nikolaos (författare)
- Univ Birmingham, Inst Head Neck Studies & Educ InHANSE, Inst Canc & Genom Sci, Birmingham, England.
-
- Brakenhoff, Ruud H. (författare)
- Vrije Univ Amsterdam, Canc Ctr Amsterdam, Otolaryngol head & neck Surg, Amsterdam UMC, Amsterdam, Netherlands.
-
- Leemans, C. Rene (författare)
- Vrije Univ Amsterdam, Canc Ctr Amsterdam, Otolaryngol head & neck Surg, Amsterdam UMC, Amsterdam, Netherlands.
-
- Jong, Robert J. Baatenburg de (författare)
- Erasmus MC Canc Ctr, Dept Otolaryngol Head & Neck Surg, Rotterdam, Netherlands.
-
- Klussmann, Jens Peter (författare)
- Univ Cologne, Med Fac, Dept Otorhinolaryngol Head & Neck Surg, Cologne, Germany.
-
- Wuerdemann, Nora (författare)
- Univ Cologne, Med Fac, Dept Otorhinolaryngol Head & Neck Surg, Cologne, Germany.
-
- Wagner, Steffen (författare)
- Univ Giessen, Dept Otorhinolaryngol Head & Neck Surg, Giessen, Germany.
-
- Dalianis, Tina (författare)
- Karolinska Institutet
-
- Marklund, Linda (författare)
- Karolinska Institutet,Uppsala universitet,Öron-, näs- och halssjukdomar,Karolinska Univ Hosp, Dept Clin Sci Intervent & Technol, Dept Oto Rhinolaryngol Head & Neck Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head & Neck, Lung & Skin Canc, Stockholm, Sweden.
-
- Mirghani, Haitham (författare)
- Gustave Roussy Canc Campus, Dept Head & Neck Oncol, Villejuif, France.
-
- Schache, Andrew (författare)
- Univ Liverpool, Liverpool Head & Neck Ctr, Dept Mol & Clin Canc Med, Liverpool, England.
-
- James, Jaqueline A. (författare)
- Queens Univ Belfast, Precis Med Ctr Excellence, Patrick G Johnston Ctr Canc Res, Belfast, North Ireland.;Belfast Hlth & Social Care Trust, Reg Mol Diagnost Serv, Belfast, North Ireland.
-
- Huang, Shao Hui (författare)
- Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Oncol Otolaryngol Head & Neck Surg, Toronto, ON, Canada.
-
- O'Sullivan, Brian (författare)
- Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Oncol Otolaryngol Head & Neck Surg, Toronto, ON, Canada.
-
- Nankivell, Paul (författare)
- Univ Birmingham, Inst Head Neck Studies & Educ InHANSE, Inst Canc & Genom Sci, Birmingham, England.
-
- Broglie, Martina A. (författare)
- Univ Zurich, Univ Hosp Zurich, Dept Otorhinolaryngol Head & Neck Surg, Zurich, Switzerland.
-
- Hoffmann, Markus (författare)
- Christian Albrechts Univ Kiel, Dept Otorhinolaryngol Head & Neck Surg, Kiel, Germany.
-
- Quabius, Elgar Susanne (författare)
- Christian Albrechts Univ Kiel, Dept Otorhinolaryngol Head & Neck Surg, Kiel, Germany.
-
- Alemany, Laia (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Barcelona, Spain.;Inst Salud Carlos III, Epidemiol & Publ Hlth, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid, Spain.
-
visa färre...
-
Univ Birmingham, Inst Head Neck Studies & Educ InHANSE, Inst Canc & Genom Sci, Birmingham, England;Univ Birmingham, Inst Head Neck Studies & Educ InHANSE, Inst Canc & Genom Sci, Birmingham B15 2TT, England. Inst Invest Biomed Bellvitge IDIBELL, Dept Med Oncol, Barcelona, Spain.;Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Barcelona, Spain.;Univ Barcelona, Dept Med, Barcelona, Spain. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
-
Ingår i: The Lancet Oncology. - : Elsevier. - 1470-2045 .- 1474-5488. ; 24:3, s. 239-251
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: p16(INK4a) (p16) immunohistochemistry is the most widely used biomarker assay for inferring HPV causation in oropharyngeal cancer in clinical and trial settings. However, discordance exists between p16 and HPV DNA or RNA status in some patients with oropharyngeal cancer. We aimed to clearly quantify the extent of discordance, and its prognostic implications.Methods: In this multicentre, multinational individual patient data analysis, we did a literature search in PubMed and Cochrane database for systematic reviews and original studies published in English between Jan 1, 1970, and Sept 30, 2022. We included retrospective series and prospective cohorts of consecutively recruited patients previously analysed in individual studies with minimum cohort size of 100 patients with primary squamous cell carcinoma of the oropharynx. Patient inclusion criteria were diagnosis with a primary squamous cell carcinoma of oropharyngeal cancer; data on p16 immunohistochemistry and on HPV testing; information on age, sex, tobacco, and alcohol use; staging by TNM 7th edition; information on treatments received; and data on clinical outcomes and follow-up (date of last follow-up if alive, date of recurrence or metastasis, and date and cause of death). There were no limits on age or performance status. The primary outcomes were the proportion of patients of the overall cohort who showed the different p16 and HPV result combinations, as well as 5-year overall survival and 5-year disease-free survival. Patients with recurrent or metastatic disease or who were treated palliatively were excluded from overall survival and disease-free survival analyses. Multivariable analysis models were used to calculate adjusted hazard ratios (aHR) for different p16 and HPV testing methods for overall survival, adjusted for prespecified confounding factors.Findings: Our search returned 13 eligible studies that provided individual data for 13 cohorts of patients with oropharyngeal cancer from the UK, Canada, Denmark, Sweden, France, Germany, the Netherlands, Switzerland, and Spain. 7895 patients with oropharyngeal cancer were assessed for eligibility. 241 were excluded before analysis, and 7654 were eligible for p16 and HPV analysis. 5714 (74middot7%) of 7654 patients were male and 1940 (25middot3%) were female. Ethnicity data were not reported. 3805 patients were p16-positive, 415 (10middot9%) of whom were HPV-negative. This proportion differed significantly by geographical region and was highest in the areas with lowest HPV-attributable fractions (r=-0middot744, p=0middot0035). The proportion of patients with p16+/HPV- oropharyngeal cancer was highest in subsites outside the tonsil and base of tongue (29middot7% vs 9middot0%, p<0middot0001). 5-year overall survival was 81middot1% (95% CI 79middot5-82middot7) for p16+/HPV+, 40middot4% (38middot6-42middot4) for p16-/HPV-, 53middot2% (46middot6-60middot8) for p16-/HPV+, and 54middot7% (49middot2-60middot9) for p16+/HPV-. 5-year disease-free survival was 84middot3% (95% CI 82middot9-85middot7) for p16+/HPV+, 60middot8% (58middot8-62middot9) for p16-/HPV-; 71middot1% (64middot7-78middot2) for p16-/HPV+, and 67middot9% (62middot5-73middot7) for p16+/HPV-. Results were similar across all European sub-regions, but there were insufficient numbers of discordant patients from North America to draw conclusions in this cohort.Interpretation: Patients with discordant oropharyngeal cancer (p16-/HPV+ or p16+/HPV-) had a significantly worse prognosis than patients with p16+/HPV+ oropharyngeal cancer, and a significantly better prognosis than patients with p16-/HPV- oropharyngeal cancer. Along with routine p16 immunohistochemistry, HPV testing should be mandated for clinical trials for all patients (or at least following a positive p16 test), and is recommended where HPV status might influence patient care, especially in areas with low HPV-attributable fractions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mehanna, Hisham
-
Taberna, Miren
-
von Buchwald, Ch ...
-
Tous, Sara
-
Brooks, Jill
-
Mena, Marisa
-
visa fler...
-
Morey, Francisca
-
Gronhoj, Christi ...
-
Rasmussen, Jacob ...
-
Garset-Zamani, M ...
-
Bruni, Laia
-
Batis, Nikolaos
-
Brakenhoff, Ruud ...
-
Leemans, C. Rene
-
Jong, Robert J. ...
-
Klussmann, Jens ...
-
Wuerdemann, Nora
-
Wagner, Steffen
-
Dalianis, Tina
-
Marklund, Linda
-
Mirghani, Haitha ...
-
Schache, Andrew
-
James, Jaqueline ...
-
Huang, Shao Hui
-
O'Sullivan, Bria ...
-
Nankivell, Paul
-
Broglie, Martina ...
-
Hoffmann, Markus
-
Quabius, Elgar S ...
-
Alemany, Laia
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
The Lancet Oncol ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet