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Prognostic factors ...
Prognostic factors for the course of beta cell function in autoimmune diabetes
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- Törn, C. (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Landin-Olsson, M. (author)
- Skåne University Hospital
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- Lernmark, Å (author)
- University of Washington
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- Palmer, JP (author)
- University of Washington
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- Arnqvist, Hans, 1943- (author)
- Linköping University,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Cellbiologi,GE: endomed
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- Blohmé, G (author)
- Stockholm South General Hospital
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- Lithner, F (author)
- Norrland University Hospital
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- Littorin, B (author)
- Malmö University
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- Nyström, L (author)
- Umeå University
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Scherstén, B (author)
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- Sundkvist, G. (author)
- Skåne University Hospital
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- Wibell, L (author)
- Uppsala University Hospital
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- Östman, J (author)
- Karolinska University Hospital
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(creator_code:org_t)
- The Endocrine Society, 2000
- 2000
- English.
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In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 85:12, s. 4619-4623
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- This study presents a 2-yr follow-up of 281 patients, aged 15-34 yr, diagnosed with diabetes between 1992 and 1993. At diagnosis, 224 (80%) patients were positive for at least one of the following autoantibodies: islet cell antibodies (ICAs), glutamic acid decarboxylase antibodies (GADAs), or tyrosine phosphatase antibodies (IA-2As), the remaining 57 (20%) patients were negative for all three autoantibodies. At diagnosis, C-peptide levels were lower (0.27, 0.16-0.40 nmol/L) in autoantibody-positive patients compared with autoantibody-negative patients (0.51, 0.28-0.78 nmol/L, P < 0.001). After 2 yr, C-peptide levels had decreased significantly in patients with autoimmune diabetes (0.20, 0.10-0.37 nmol/L, P = 0.0018), but not in autoantibody-negative patients. In patients with autoimmune diabetes, a low initial level of C-peptide (odds ratio, 2.6, 95% confidence interval, 1.7-4.0) and a high level of GADAs (odds ratio, 2.5, 95% confidence interval, 1.1-5.7) were risk factors for a C-peptide level below the reference level of 0.25 nmol/L 2 yr after diagnosis. Body mass index had a significant effect in the multivariate analysis only when initial C-peptide was not considered. Factors such as age, gender, levels of ICA or IA-2A or insulin autoantibodies (analyzed in a subset of 180 patients) had no effect on the decrease in ▀-cell function. It is concluded that the absence of pancreatic islet autoantibodies at diagnosis were highly predictive for a maintained ▀-cell function during the 2 yr after diagnosis, whereas high levels of GADA indicated a course of decreased ▀-cell function with low levels of C-peptide. In autoimmune diabetes, an initial low level of C-peptide was a strong risk factor for a decrease in ▀-cell function and conversely high C-peptide levels were protective. Other factors such as age, gender, body mass index, levels of ICA, IA-2A or IAA had no prognostic importance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Törn, C.
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Landin-Olsson, M ...
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Lernmark, Å
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Palmer, JP
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Arnqvist, Hans, ...
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Blohmé, G
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show more...
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Lithner, F
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Littorin, B
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Nyström, L
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Scherstén, B
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Sundkvist, G.
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Wibell, L
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Östman, J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Linköping University
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Lund University
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Karolinska Institutet