Search: WFRF:(Telemo Esbjörn 1953) >
A kinetic study in ...
A kinetic study in adults with food hypersensitivity assessed as eosinophil activation in fecal samples
-
- Magnusson, J (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
-
- Gellerstedt, Martin, 1966- (author)
- Högskolan Väst,Avd för datavetenskap och informatik,Department for Studies of Work, Economics and Health, The University of Trollhättan/Uddevalla, Sweden
-
- Ahlstedt, S (author)
- Karolinska Institutet
-
show more...
-
- Andersson, Bengt A., 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology
-
- Bengtsson, Ulf, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology
-
- Telemo, Esbjörn, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
-
- Hansson, Tony (author)
- Institute Environmental Medicine, Karolinska Institute, Stockholm, Sweden ; Pharmacia Diagnostics AB, Uppsala, Sweden ; Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
-
- Peterson, C G B (author)
- Institute Environmental Medicine, Karolinska Institute, Stockholm, Sweden
-
show less...
-
(creator_code:org_t)
- 2003-08-05
- 2003
- English.
-
In: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 33:8, s. 1052-1059.
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Immune-mediated food hypersensitivity affecting the gut is difficult to evaluate, and objective tools to diagnose local gastrointestinal (GI) inflammatory reactions are lacking. OBJECTIVES: To determine whether allergic manifestations in adults with a history of food-related GI symptoms could be assessed in feces during symptomatic and non-symptomatic periods, using the surrogate markers, eosinophil cationic protein (ECP), eosinophil protein X (EPX) and myeloperoxidase (MPO). METHODS: Thirteen subjects with food hypersensitivity-related GI symptoms, confirmed by a positive double-blind placebo-controlled food challenge (DBPCFC), were subjected to an open kinetic food challenge design for 6 weeks. Symptoms were recorded and scored during the 3-week study period and stool samples were obtained every day. The surrogate markers ECP, EPX and MPO were measured in the supernatants from feces samples. RESULTS: A significant increase in abdominal pain, distension and flatulence was observed during challenge, with a gradual decrease during elimination diet. Both between days and subjects, EPX levels were more frequently increased compared to ECP and MPO. Individuals with a history of a short duration of symptoms had significantly higher mean levels of EPX and MPO than those with a longer duration of symptoms. CONCLUSIONS: An overall increase in levels of eosinophil markers, in particular EPX, was observed in feces from patients with food-related GI symptoms. However, rather than being a tool to differentiate symptomatic from non-symptomatic periods, EPX might be used for detecting an ongoing clinical or subclinical chronic inflammation, that may have an impact on the patient's clinical course of GI symptoms.
Subject headings
- SAMHÄLLSVETENSKAP -- Medie- och kommunikationsvetenskap -- Systemvetenskap, informationssystem och informatik med samhällsvetenskaplig inriktning (hsv//swe)
- SOCIAL SCIENCES -- Media and Communications -- Information Systems, Social aspects (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- eosinophil cationic protein
- eosinophil protein X
- fecal samples
- food-induced gastrointestinal
- Vårdvetenskap
- Nursing science
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Magnusson, J
-
Gellerstedt, Mar ...
-
Ahlstedt, S
-
Andersson, Bengt ...
-
Bengtsson, Ulf, ...
-
Telemo, Esbjörn, ...
-
show more...
-
Hansson, Tony
-
Peterson, C G B
-
show less...
- About the subject
-
- SOCIAL SCIENCES
-
SOCIAL SCIENCES
-
and Media and Commun ...
-
and Information Syst ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nursing
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Clinical and Exp ...
- Clin Exp Allergy
- By the university
-
University West
-
Uppsala University
-
University of Skövde
-
Karolinska Institutet
-
University of Gothenburg