WFRF:(HALL P)
Search: WFRF:(HALL P) > (1990-1994) > Structure of the C-...
- 3 of 4
- Previous record
- Next record
- To hitlist
- Hall, MichaelUmeå universitet,Kemiska institutionen (author)
Structure of the C-terminal domain of AspA (antigen I/II-family) protein from Streptococcus pyogenes
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2014-03-12
- Elsevier,2014
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-79210
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79210URI
- https://doi.org/10.1016/j.fob.2014.02.012DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins found on the surfaces of most oral streptococci and are involved in host colonization and biofilm formation. In the present study we have determined the crystal structure of the C2–3-domain of the antigen I/II type protein AspA from S. pyogenes M type 28. The structure was solved to 1.8 Å resolution and shows that the C2–3-domain is comprised of two structurally similar DEv-IgG motifs, designated C2 and C3, both containing a stabilizing covalent isopeptide bond. Furthermore a metal binding site is identified, containing a bound calcium ion. Despite relatively low sequence identity, interestingly, the overall structure shares high similarity to the C2–3-domains of antigen I/II proteins from Streptococcus gordonii and Streptococcus mutans, although certain parts of the structure exhibit distinct features. In summary this work constitutes the first step in the full structure determination of the AspA protein from S. pyogenes.
Subject headings and genre
- NATURVETENSKAP Biologi Strukturbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Structural Biology hsv//eng
- crystal structure
- adhesin
- streptococci
- isopeptide
- biologisk kemi
- biological chemistry
- Biochemistry
- biokemi
Added entries (persons, corporate bodies, meetings, titles ...)
- Nylander, ÅsaUmeå universitet,Tandläkarutbildning(Swepub:umu)asanyr01 (author)
- Jenkinson, H.University of Bristol (author)
- Persson, KarinaUmeå universitet,Kemiska institutionen(Swepub:umu)kape0001 (author)
- Umeå universitetKemiska institutionen (creator_code:org_t)
Related titles
- In:FEBS Open Bio: Elsevier4, s. 283-2892211-5463
Internet link
- https://doi.org/10.1016/j.fob.2014.02.012Fulltext
- https://umu.diva-portal.org/smash/get/diva2:640267/FULLTEXT01.pdffulltext:print
- https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.fob.2014.02.012
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79210
- https://doi.org/10.1016/j.fob.2014.02.012
Find in a library
- FEBS Open Bio (Search for host publication in LIBRIS)
To the university's database
- 3 of 4
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Hall, Michael
- Nylander, Åsa
- Jenkinson, H.
- Persson, Karina
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Structural Biolo ...
- Articles in the publication
- FEBS Open Bio
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
