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- Mørk, CatoDepartment of Dermatology, Rikshospitalet University Hospital, Norway (författare)
The Prostaglandin E1 Analog Misoprostol Reduces Symptoms and Microvascular Arteriovenous Shunting in Erythromelalgia : A Double-Blind, Crossover, Placebo-Compared Study
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
- Nature Publishing Group,2004
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:kau-2218
- https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-2218URI
- https://doi.org/10.1111/j.0022-202X.2004.22339.xDOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-24700URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-22156URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-3195URI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- Based on previous experience with parenteral prostanoids, we studied the effect of misoprostol treatment, an orally administered prostaglandin E1 analog, in patients with erythromelalgia. Treatment with placebo was followed by treatment with misoprostol (0.4–0.8 mg per d), both for 6 wk. The patients (n=21) and a study nurse who administered the trial were blinded. The endpoints were change in pain and need for cooling and global assessment of the treatment. Following central body heat provocation, global skin perfusion, capillary morphology, and change in pain were also recorded before and after each treatment period. Results were compared with data from healthy control subjects (n=11) that did not undergo treatment. Clinical safety and tolerability evaluation included physical examinations, clinical laboratory tests, and monitoring of adverse events. All clinical outcome measures were significantly better after treatment with misoprostol (p<0.01) as compared with placebo treatment and after a 3-mo follow-up without treatment. The heat-induced increase in global perfusion after misoprostol treatment was similar to the control group and significantly lower when compared with baseline (p<0.01) and placebo treatment (p<0.05), respectively. This study demonstrates that misoprostol is clinically superior to placebo in patients with erythromelalgia. The results of the perfusion studies may imply that the mechanism of action of the beneficial effect of misoprostol is reduced microvascular arteriovenous shunting in affected skin.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
- NATURVETENSKAP Data- och informationsvetenskap Datorseende och robotik hsv//swe
- NATURAL SCIENCES Computer and Information Sciences Computer Vision and Robotics hsv//eng
- arteriovenous shunting
- clinical trial
- microcirculation
- prostanoids
- Dermatology and venerology
- Dermatologi och venerologi
- MEDICINE
- Image analysis
- Biomedicinsk lab. Vetenskap
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Salerud, Göran,1954-Linköpings universitet,Tekniska högskolan,Biomedicinsk instrumentteknik,Department of Biomedical Engineering, Linköping University(Swepub:liu)gorsa75 (författare)
- Asker, Claes L,1966-Karlstads universitet,Institutionen för kemi(Swepub:kau)claeaske (författare)
- Kvernebo, KnutDepartment of Cardiothoracic Surgery, Ullevaal University Hospital, Norway (författare)
- Department of Dermatology, Rikshospitalet University Hospital, NorwayTekniska högskolan (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Investigative Dermatology: Nature Publishing Group122:3, s. 587-5930022-202X1523-1747
- Ingår i:Journal of Investigative Dermatology Volume 122, Issue 3, Page 587-593, Mar 2004: Nature Publishing Group122:3, s. 587-593
Internetlänk
- https://kau.diva-portal.org/smash/get/diva2:24558/FULLTEXT01.pdffulltext:preprint
- http://dx.doi.org/10.1111/j.0022-202X.2004.22339.x
- http://kau.diva-portal.org/smash/get/diva2:128368/FULLTEXT01
- http://www.nature.com/jid/journal/v122/n3/full/5602219a.html
- https://kau.diva-portal.org/smash/get/diva2:128368/FULLTEXT01.pdffulltext:postprint
- https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-2218
- https://doi.org/10.1111/j.0022-202X.2004.22339.x
- https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-24700
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-22156
- https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-3195
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- Journal of Investigative Dermatology (Sök värdpublikationen i LIBRIS)
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