Sökning: (AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology)) srt2:(2010-2014) lar1:(lnu) >
Is acetylcholine a ...
Is acetylcholine a signaling molecule for human colon cancer progression?
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- Novotny, Ann, 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Acad, Dept Surg, Gothenburg, Sweden.,University of Gothenburg
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- Ryberg, Kristin (författare)
- Karlstads universitet,Avdelningen för kemi och biomedicinsk vetenskap,Karlstad University
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- Ullmark, Jenny Heiman, 1980 (författare)
- Kungalv Dist Hosp, Dept Surg, Kungalv, Sweden.
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- Nilsson, Linn (författare)
- Vaxjo Cent Hosp, Dept Surg, Vaxjo, Sweden.,Kungälv District Hospital
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- Khorram-Manesh, Amir, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Acad, Prehosp & Disaster Med Ctr, Gothenburg, Sweden.,Växjö Central Hospital
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- Nordgren, Svante, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Acad, Dept Surg, Gothenburg, Sweden.,University of Gothenburg
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- Delbro, Dick, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Acad, Dept Surg, Gothenburg, Sweden.;Karlstad Univ, Dept Chem & Biomed Sci, Karlstad, Sweden.,University of Gothenburg ; Karlstad University
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- Nylund, Gunnar (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Sodra Alvsborgs Hosp, Dept Surg, SE-50182 Boras, Sweden.,Södra Älvsborg's Hospital
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(creator_code:org_t)
- 2011-01-26
- 2011
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 46:4, s. 446-455
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective. Non-neuronal acetylcholine (ACh) has been suggested to be a mediator for the development of various types of cancer. We analyzed a possible role for this molecule in carcinogenesis and/or progression of human colon cancer, in patient biopsies harvested from the colon during surgery. We addressed whether ACh synthesis (by choline acetyltransferase) and/or degradation (by ACh esterase), as well as the expression of the alpha alpha 7-subtype of the nicotinic ACh receptors, and the peptide ligand at the alpha alpha 7 receptors, secreted mammalian Ly6/urokinase-type plasminogen activator receptor-related protein-1, respectively, are deranged in tumor tissue as compared with macroscopically tumor-free colon tissue. Methods. A total of 38 patients were grouped for analysis based on their respective Dukes stage (either Dukes A ++ B or C ++ D). A mucosal tissue sample was harvested from macroscopically tumor-free colon tissue (i.e. control tissue), as well as from the tumor, and protein lysates were prepared for quantitative Western blotting. Full-thickness specimens were taken for immunohistochemistry. Results. For all the above named markers, there was a significant difference between control and tumor tissue with regard to protein levels, and there was, in addition, a significant difference in protein levels between the Dukes A ++ B and C ++ D groups. Conclusion. The current findings may suggest a role for ACh in colon carcinogenesis/cancer progression; the data obtained could have prognostic and/or therapeutic significance for this disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Acetylcholine
- choline acetyltransferase
- colon cancer
- nicotinic acetylcholine receptor
- SLURP-1
- Biomedical Sciences
- Biomedicinsk vetenskap
- Natural Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Novotny, Ann, 19 ...
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Ryberg, Kristin
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Ullmark, Jenny H ...
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Nilsson, Linn
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Khorram-Manesh, ...
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Nordgren, Svante ...
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Delbro, Dick, 19 ...
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Nylund, Gunnar
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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MEDICIN OCH HÄLS ...
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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Scandinavian Jou ...
- Av lärosätet
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Karlstads universitet
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Göteborgs universitet
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