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Prenatal Bisphenol ...
Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans
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- Alavian-Ghavanini, Ali (author)
- Karolinska Institute
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- Lin, Ping-I (author)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Karlstad Univ, Dept Hlth Sci, S-65188 Karlstad, Sweden
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- Lind, P. Monica, 1957- (author)
- Uppsala University,Uppsala universitet,Arbets- och miljömedicin
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- Rimfors, Sabina Risen (author)
- Karolinska Institute
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- Lejonklou, Margareta Halin, 1966- (author)
- Uppsala University,Uppsala universitet,Arbets- och miljömedicin
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- Dunder, Linda (author)
- Uppsala University,Uppsala universitet,Arbets- och miljömedicin
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- Tang, Mandy (author)
- Karolinska Institute
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- Lindh, Christian (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Bornehag, Carl-Gustaf, 1957- (author)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine Mt Sinai, New York, USA,Icahn Sch Med Mt Sinai, New York, NY 10029 USA;Karlstad Univ, Dept Hlth Sci, S-65188 Karlstad, Sweden,Icahn School of Medicine at Mount Sinai
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- Rueegg, Joelle (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Unit Toxicol Sci, Swetox, Forskargatan 20, S-15136 Sodertalje, Sweden;Karolinska Inst, Dept Clin Neurosci, CMM, S-17164 Solna, Sweden
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(creator_code:org_t)
- 2018-07-27
- 2018
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 8
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Bisphenol A (BPA) exposure has been linked to neurodevelopmental disorders and to effects on epigenetic regulation, such as DNA methylation, at genes involved in brain function. High doses of BPA have been shown to change expression and regulation of one such gene, Grin2b, in mice. Yet, if such changes occur at relevant doses in animals and humans has not been addressed. We investigated if low-dose developmental BPA exposure affects DNA methylation and expression of Grin2b in brains of adult rats. Furthermore, we assessed associations between prenatal BPA exposure and Grin2b methylation in 7-year old children. We found that Grin2b mRNA expression was increased and DNA methylation decreased in female, but not in male rats. In humans, prenatal BPA exposure was associated with increased methylation levels in girls. Additionally, Iow APGAR scores, a predictor for increased risk for neurodevelopmental diseases, were associated with higher Grin2b methylation levels in girls. Thus, we could link developmental BPA exposure and Iow APGAR scores to changes in the epigenetic regulation of Grin2b, a gene important for neuronal function, in a sexual dimorphic fashion. Discrepancies in exact locations and directions of the DNA methylation change might reflect differences between species, analysed tissues, exposure level and/or timing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Public Health Science
- Folkhälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alavian-Ghavanin ...
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Lin, Ping-I
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Lind, P. Monica, ...
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Rimfors, Sabina ...
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Lejonklou, Marga ...
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Dunder, Linda
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Tang, Mandy
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Lindh, Christian
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Bornehag, Carl-G ...
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Rueegg, Joelle
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Karlstad University
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Karolinska Institutet
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Uppsala University
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Lund University