M2 macrophages and regulatory T cells in lethal prostate cancer.

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MARC

Erlandsson, Ann,1968-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University (author)

M2 macrophages and regulatory T cells in lethal prostate cancer.

Article/chapterEnglish2019

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2018-11-30
John Wiley & Sons,2019
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:kau-71932
https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-71932URI
https://doi.org/10.1002/pros.23742DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70404URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154012URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BACKGROUND: Prostate cancer (PCa) is one of the most frequently diagnosed cancers in the world. Emerging evidence suggests that inflammatory cells such as M2 macrophages and regulatory T cells (Tregs ) can contribute to cancer progression by suppressing the anti-tumor immune response. This study investigated the number of CD163-positive M2 macrophages in PCa tissue. It also investigated the correlation and interaction of M2 macrophages and Tregs .METHODS: This nested case-control study included subjects from a cohort of men diagnosed with PCa as an incidental finding during transurethral resection of the prostate. The cases were 225 men who died from PCa, and the controls were 367 men who survived more than 10 years after PCa diagnosis without disease progression. Infiltrating CD163-positive M2 macrophages and FOXP3/CD4-positive Tregs in PCa tissue were identified using immunohistochemistry. The correlation and interaction of M2 macrophages and Tregs were assessed using Spearman's rank-order correlation and a likelihood test, respectively. Logistic regression was used to estimate odds ratios (ORs) for lethal PCa and macrophage counts.RESULTS: The number of M2 macrophages and Tregs showed a significant correlation (P < 0.001) but no interactions. The OR for lethal PCa was 1.93 (95%CI: 1.23-3.03) for men with high numbers of M2 macrophages. Also for cases with uncertain outcome (GS categories 3 + 4 and 4 + 3) high numbers of M2 macrophages does predict a poorer prognosis.CONCLUSIONS: Our data showed that men with high numbers of M2 macrophages in the prostate tumor environment had increased odds of dying of PCa. It is possible that M2 macrophages, together with other suppressor cells such as Tregs , promote an immunosuppressive environment.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
CD163
FOXP3
TAMs
Tregs
Public Health Science
Folkhälsovetenskap

Added entries (persons, corporate bodies, meetings, titles ...)

Carlsson, Jessica,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University(Swepub:oru)jccn (author)
Lundholm, Marie,1974-Umeå universitet,Patologi,Umeå University(Swepub:umu)malu0007 (author)
Fält, AnnaSchool of Medical Sciences, Örebro University, Örebro, Sweden,Clinical Epidemiology and Biostatistics (author)
Andersson, Sven-OlofDepartment of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (author)
Andrén, Ove,1963-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University(Swepub:oru)oan (author)
Davidsson, Sabina,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University(Swepub:oru)sdn (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:The Prostate: John Wiley & Sons79:4, s. 363-3690270-41371097-0045

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

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