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A Novel Approach to...
A Novel Approach to Chemical Mixture Risk Assessment—Linking Data from Population-Based Epidemiology and Experimental Animal Tests
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- Bornehag, Carl-Gustaf, 1957- (författare)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai, United States
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- Kitraki, Efthymia (författare)
- National and Kapodistrian University of Athens, Greece
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- Stamatakis, Antonios (författare)
- National and Kapodistrian University of Athens, Greece
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- Panagiotidou, Emily (författare)
- National and Kapodistrian University of Athens, Greece
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- Rudén, Christina (författare)
- Stockholm University,Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Stockholm University, Sweden
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- Shu, Huan (författare)
- Stockholm University,Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Stockholm University, Sweden
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- Lindh, Christian (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups,Lund University, Sweden
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- Ruegg, Joelle (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Sweden
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- Gennings, Chris (författare)
- Icahn School of Medicine at Mount Sinai, United States
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(creator_code:org_t)
- 2019-06-07
- 2019
- Engelska.
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Ingår i: Risk Analysis. - : John Wiley & Sons. - 0272-4332 .- 1539-6924. ; 39:10, s. 2259-2271
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Abstract
Ämnesord
Stäng
- Humans are continuously exposed to chemicals with suspected or proven endocrine disrupting chemicals (EDCs). Risk management of EDCs presents a major unmet challenge because the available data for adverse health effects are generated by examining one compound at a time, whereas real-life exposures are to mixtures of chemicals. In this work, we integrate epidemiological and experimental evidence toward a whole mixture strategy for risk assessment. To illustrate, we conduct the following four steps in a case study: (1) identification of single EDCs (“bad actors”)—measured in prenatal blood/urine in the SELMA study—that are associated with a shorter anogenital distance (AGD) in baby boys; (2) definition and construction of a “typical” mixture consisting of the “bad actors” identified in Step 1; (3) experimentally testing this mixture in an in vivo animal model to estimate a dose–response relationship and determine a point of departure (i.e., reference dose [RfD]) associated with an adverse health outcome; and (4) use a statistical measure of “sufficient similarity” to compare the experimental RfD (from Step 3) to the exposure measured in the human population and generate a “similar mixture risk indicator” (SMRI). The objective of this exercise is to generate a proof of concept for the systematic integration of epidemiological and experimental evidence with mixture risk assessment strategies. Using a whole mixture approach, we could find a higher rate of pregnant women under risk (13%) when comparing with the data from more traditional models of additivity (3%), or a compound-by-compound strategy (1.6%).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Chemical exposure
- mixtures
- risk assessment
- sexual development
- Animals
- Chemicals
- Endocrine disrupters
- Health risks
- Population statistics
- Risk management
- Risk perception
- Adverse health effects
- Assessment strategies
- Endocrine disrupting chemicals
- Experimental evidence
- Statistical measures
- Systematic integration
- Public Health Science
- Folkhälsovetenskap
- Chemical exposure
- mixtures
- risk assessment
- sexual development
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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