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Using the delayed s...
Using the delayed spatial alternation task to assess environmentally associated changes in working memory in very young children
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- Horton, Megan K. (författare)
- Icahn School of Medicine at Mount Sinai, United States
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- Zheng, Laura (författare)
- Icahn School of Medicine at Mount Sinai, United States
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- Williams, Ashley (författare)
- Icahn School of Medicine at Mount Sinai, United States
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- Doucette, John T. (författare)
- Icahn School of Medicine at Mount Sinai, United States
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- Svensson, Katherine (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)
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- Cory-Slechta, Deborah (författare)
- University of Rochester Medical Center, United States
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- Tamayo-Ortiz, Marcela (författare)
- Instituto Nacional de Salud Pública, Mexico; National Council of Science and Technology, CONTACY, Mexico
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- Torres-Calapiz, Mariana (författare)
- Instituto Nacional de Salud Pública, Mexico
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- Bellinger, David (författare)
- Harvard Medical School, United States
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- Schnaas, Lourdes (författare)
- Instituto Nacional de Perinatología, Mexico
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- Tellez Rojo, Martha Maria (Mara) (författare)
- Instituto Nacional de Salud Pública, Mexico
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- Wright, Robert (författare)
- Icahn School of Medicine at Mount Sinai, United States
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: Neurotoxicology. - : Elsevier. - 0161-813X .- 1872-9711. ; 77, s. 71-79
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Working memory (WM) is critical for problem solving and reasoning. Beginning in infancy, children show WM capacity increasing with age but there are few validated tests of WM in very young children. Because rapid brain development may increase susceptibility to adverse impacts of prenatal neurotoxicant exposure, such as lead, tests of WM in very young children would help to delineate onset of developmental problems and windows of susceptibility. Purpose: Our objective was to assess the feasibility of administering a Delayed Spatial Alternation Task (DSAT) to measure WM among 18- and 24-month old children enrolled in an ongoing longitudinal birth cohort study and compare DSAT performance with age and general cognitive development. We further explored whether prenatal lead exposure impacted DSAT performance. Methods: We assessed 457 mother-child pairs participating in the Programming Research in Obesity, GRowth, Environment and Social Stressors (PROGRESS) Study in Mexico City. The DSAT and Bayley Scales of Infant Development (BSID-III) were administered at 18- and 24-months. Lead was measured in maternal blood collected during pregnancy (MBPb) and in a subsample of children at 24-months (CBPb). We regressed DSAT measures on MBPb and CBPb, child sex, and maternal age, education, socioeconomic status, and household smoking. We compared DSAT performance to BSID-III performance with adjusted residuals. Results: 24-month children perform better on the DSAT than 18-month children; 24-month subjects reached a higher level on the DSAT (3.3 (0.86) vs. 2.4 (0.97), p < 0.01), and had a higher number of correct responses (20.3 vs. 17.2, p < 0.01). In all DSAT parameters, females performed better than males. Maternal education predicted better DSAT performance; household smoking predicted worse DSAT performance. A higher number of correct responses was associated with higher BSID-III Cognitive scales at 18 months (r = 0.20, p < 0.01) and 24 months (r = 0.27, p < 0.01). MBPb and CPBb did not significantly predict DSAT performance. Conclusion: Improved performance on the DSAT with increasing age, the positive correlation with the BSID-III cognitive and language scales and the correlation with common sociodemographic predictors of neurodevelopment demonstrate the validity of the DSAT as a test of infant development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Working memory
- Neurodevelopment
- Children
- Lead
- Delayed spatial alternation
- Public Health Science
- Folkhälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Horton, Megan K.
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Zheng, Laura
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Williams, Ashley
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Doucette, John T ...
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Svensson, Kather ...
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Cory-Slechta, De ...
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visa fler...
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Tamayo-Ortiz, Ma ...
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Torres-Calapiz, ...
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Bellinger, David
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Schnaas, Lourdes
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Tellez Rojo, Mar ...
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Wright, Robert
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Neurotoxicology
- Av lärosätet
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Karlstads universitet