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Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project

Kortenkamp, Andreas (författare)
Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
Axelstad, Marta (författare)
DTU Technical University of Denmark, Denmark,National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
Baig, Asma H. (författare)
Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
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Bergman, Åke, 1950- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University, Sweden
Bornehag, Carl-Gustav, 1957- (författare)
Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Department of Health Sciences, Karlstad University, Karlstad, Sweden
Cenijn, Peter (författare)
Vrije University, NLD,Department of Environment and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Christiansen, Sofie (författare)
National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
Demeneix, Barbara (författare)
CNRS, FRA,Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique, Paris, France
Derakhshan, Arash (författare)
Erasmus MC, Academy, NLD,Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
Fini, Jean-Baptiste (författare)
Charité – Universitätsmedizin Berlin, DEU,Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique, Paris, France
Fraedrich, Caroline (författare)
Charité – Universitätsmedizin Berlin, DEU,Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany
Hamers, Timo (författare)
Department of Environment and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Hellwig, Lina (författare)
Dept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany; Charité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany
Koehrle, Josef (författare)
Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany
Korevaar, Tim I. M. (författare)
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
Lindberg, Johan (författare)
RISE,Kemiska processer och läkemedel
Martin, Olwenn (författare)
Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
Meima, Marcel E. (författare)
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
Mergenthaler, Philipp (författare)
Dept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany
Nikolov, Nikolai (författare)
DTU Technical University of Denmark, Denmark,National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
Du Pasquier, David (författare)
Lab Watchfrog, FRA,Laboratoire Watchfrog, Evry, France
Peeters, Robin P. (författare)
Erasmus MC, NLD,Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
Platzack, Bjorn (författare)
RISE,Kemiska processer och läkemedel
Ramhoj, Louise (författare)
National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
Remaud, Sylvie (författare)
Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique CNRS 7, Paris, France
Renko, Kostja (författare)
Charité – Universitätsmedizin Berlin, DEU,Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany
Scholze, Martin (författare)
Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK
Stachelscheid, Harald (författare)
Charité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany
Svingen, Terje (författare)
National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
Wagenaars, Fabian (författare)
Department of Environment and Health, Vrije Universiteit Amsterdam, VUA, Amsterdam, The Netherlands
Wedebye, Eva Bay (författare)
National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark
Zoeller, R. Thomas, 1952- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Orebro University, Sweden
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 (creator_code:org_t)
2020-04-28
2020
Engelska.
Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 21:9
Relaterad länk:
https://doi.org/10.3...
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https://kau.diva-por... (primary) (Raw object)
https://www.mdpi.com...
https://ri.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood-brain and blood-placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)

Nyckelord

endocrine disruptors
thyroid hormone system
brain development
test method development
test method validation
risk assessment
Biology
Biologi

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