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  • Kortenkamp, AndreasBrunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK (författare)

Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-04-28
  • MDPI,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kau-78184
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-78184URI
  • https://doi.org/10.3390/ijms21093123DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81447URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-45043URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:European Union (EU) 825161
  • The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood-brain and blood-placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Axelstad, MartaDTU Technical University of Denmark, Denmark,National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark (författare)
  • Baig, Asma H.Brunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK (författare)
  • Bergman, Åke,1950-Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University, Sweden(Swepub:oru)akbn (författare)
  • Bornehag, Carl-Gustav,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Department of Health Sciences, Karlstad University, Karlstad, Sweden(Swepub:ri)carl-gustav.bornehag@ri.se (författare)
  • Cenijn, PeterVrije University, NLD,Department of Environment and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (författare)
  • Christiansen, SofieNational Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark (författare)
  • Demeneix, BarbaraCNRS, FRA,Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique, Paris, France (författare)
  • Derakhshan, ArashErasmus MC, Academy, NLD,Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands (författare)
  • Fini, Jean-BaptisteCharité – Universitätsmedizin Berlin, DEU,Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique, Paris, France (författare)
  • Fraedrich, CarolineCharité – Universitätsmedizin Berlin, DEU,Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Hamers, TimoDepartment of Environment and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. (författare)
  • Hellwig, LinaDept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany; Charité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Koehrle, JosefDepartment of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Korevaar, Tim I. M.Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands (författare)
  • Lindberg, JohanRISE,Kemiska processer och läkemedel (författare)
  • Martin, OlwennBrunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK (författare)
  • Meima, Marcel E.Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands (författare)
  • Mergenthaler, PhilippDept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany (författare)
  • Nikolov, NikolaiDTU Technical University of Denmark, Denmark,National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark (författare)
  • Du Pasquier, DavidLab Watchfrog, FRA,Laboratoire Watchfrog, Evry, France (författare)
  • Peeters, Robin P.Erasmus MC, NLD,Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands (författare)
  • Platzack, BjornRISE,Kemiska processer och läkemedel(Swepub:ri)bjorn.platzack@ri.se (författare)
  • Ramhoj, LouiseNational Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark (författare)
  • Remaud, SylvieUnité PhyMA Laboratory, Adaptation du Vivant, Muséum national d'Histoire naturelle, Centre National de la Recherche Scientifique CNRS 7, Paris, France (författare)
  • Renko, KostjaCharité – Universitätsmedizin Berlin, DEU,Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Scholze, MartinBrunel University, GBR,Institute of Environment, Health and Societies, Brunel University London, UK (författare)
  • Stachelscheid, HaraldCharité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany (författare)
  • Svingen, TerjeNational Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark (författare)
  • Wagenaars, FabianDepartment of Environment and Health, Vrije Universiteit Amsterdam, VUA, Amsterdam, The Netherlands (författare)
  • Wedebye, Eva BayNational Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,DTU Technical University of Denmark, Denmark (författare)
  • Zoeller, R. Thomas,1952-Örebro universitet,Institutionen för naturvetenskap och teknik,Orebro University, Sweden(Swepub:oru)tzr (författare)
  • Brunel University, GBRInstitute of Environment, Health and Societies, Brunel University London, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Molecular Sciences: MDPI21:91661-65961422-0067

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