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Long term transcrip...
Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment
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- Repouskou, Anastasia (författare)
- Natl & Kapodistrian Univ Athens NKUA, Sch Hlth Sci, Fac Dent, Basic Sci Lab, Athens, Greece.,National and Kapodistrian University of Athens
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- Papadopoulou, Anastasia-Konstantina (författare)
- Natl & Kapodistrian Univ Athens NKUA, Sch Hlth Sci, Fac Dent, Basic Sci Lab, Athens, Greece.;NKUA, Sch Hlth Sci, Fac Nursing, Biol Biochem Lab, Athens, Greece.,National and Kapodistrian University of Athens
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- Panagiotidou, Emily (författare)
- Natl & Kapodistrian Univ Athens NKUA, Sch Hlth Sci, Fac Dent, Basic Sci Lab, Athens, Greece.;NKUA, Sch Hlth Sci, Fac Nursing, Biol Biochem Lab, Athens, Greece.,National and Kapodistrian University of Athens
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- Trichas, Panagiotis (författare)
- NKUA, Sch Hlth Sci, Fac Nursing, Biol Biochem Lab, Athens, Greece.,National and Kapodistrian University of Athens
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- Lindh, Christian (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Bergman, Åke (författare)
- Stockholms universitet,Institutionen för miljövetenskap,Stockholm University,Stockholm Univ, Dept Environm Sci, SE-10691 Stockholm, Sweden.
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- Gennings, Chris (författare)
- Icahn Sch Med Mt Sinai, New York, NY 10029 USA.,Icahn School of Medicine at Mount Sinai
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- Bornehag, Carl-Gustav, 1957- (författare)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn Sch Med Mt Sinai, New York, NY 10029 USA.;Karlstad Univ, Karlstad, Sweden.,Icahn School of Medicine at Mount Sinai
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- Ruegg, Joelle (författare)
- Uppsala University,Uppsala universitet,Miljötoxikologi
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- Kitraki, Efthymia (författare)
- Natl & Kapodistrian Univesity, GRC,Natl & Kapodistrian Univ Athens NKUA, Sch Hlth Sci, Fac Dent, Basic Sci Lab, Athens, Greece.,National and Kapodistrian University of Athens
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- Stamatakis, Antonios (författare)
- Natl & Kapodistrian Univesity, GRC,NKUA, Sch Hlth Sci, Fac Nursing, Biol Biochem Lab, Athens, Greece.,National and Kapodistrian University of Athens
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Natl & Kapodistrian Univ Athens NKUA, Sch Hlth Sci, Fac Dent, Basic Sci Lab, Athens, Greece National and Kapodistrian University of Athens (creator_code:org_t)
- 2020-06-09
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 10, s. 1-8
- Relaterad länk:
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https://doi.org/10.1...
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https://kau.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Accumulating evidence suggests that gestational exposure to endocrine disrupting chemicals (EDCs) may interfere with normal brain development and predispose for later dysfunctions. The current study focuses on the exposure impact of mixtures of EDCs that better mimics the real-life situation. We herein describe a mixture of phthalates, pesticides and bisphenol A (mixture N1) detected in pregnant women of the SELMA cohort and associated with language delay in their children. To study the long-term impact of developmental exposure to N1 on brain physiology and behavior we administered this mixture to mice throughout gestation at doses 0x, 0.5x, 10x, 100x and 500x the geometric mean of SELMA mothers' concentrations, and examined their offspring in adulthood. Mixture N1 exposure increased active coping during swimming stress in both sexes, increased locomotion and reduced social interaction in male progeny. The expression of corticosterone receptors, their regulator Fkbp5, corticotropin releasing hormone and its receptor, oxytocin and its receptor, estrogen receptor beta, serotonin receptors (Htr1a, Htr2a) and glutamate receptor subunit Grin2b, were modified in the limbic system of adult animals, in a region-specific, sexually-dimorphic and experience-dependent manner. Principal component analysis revealed gene clusters associated with the observed behavioral responses, mostly related to the stress axis. This integration of epidemiology-based data with an experimental model increases the evidence that prenatal exposure to EDC mixtures impacts later life brain functions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Pituitary-Adrenal Axis
- Perinatal Exposure
- Gene-Expression
- Oxytocin
- Anxiety
- Mechanisms
- Chemicals
- Phthalate
- Estrogen
- Rats
- Public Health Science
- Folkhälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Repouskou, Anast ...
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Papadopoulou, An ...
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Panagiotidou, Em ...
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Trichas, Panagio ...
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Lindh, Christian
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Bergman, Åke
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Gennings, Chris
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Bornehag, Carl-G ...
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Ruegg, Joelle
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Kitraki, Efthymi ...
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Stamatakis, Anto ...
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